2-(2-甲氧基-2-氧代乙基)苯羧酸甲酯合成路线 （共 48 条）
反应条件
1: With sulfuric acid in methanol; water T=5°C; 24 h; Heating / reflux; 2: With sodium hydroxide in methanol; water
参考文献
INOTEK PHARMACEUTICALS CORPORATION
Patent: WO2007/117289 A2, 2007 ;
Location in patent: Page/Page column 107 ;
反应条件
thionyl chloride 2 h; Reflux;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN RandD; UNIVERSITE DE LILLE; CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE; ECOLE NATIONALE SUPERIEURE DE CHIMIE DE LILLE; BAILLY, Fabrice; BILLAMBOZ, Muriel; CHRIST, Frauke; COTELLE, Philippe; DEBYSER, Zeger; LION, Cedric; SUCHAUD, Virginie
Patent: WO2012/85003 A1, 2012 ;
Location in patent: Page/Page column 62 ;
WO 2012/085003 A1
反应条件
thionyl chloride T=25 - 27°C; Esterification; 10 h;
参考文献
Journal of Chemical Research - Part S, , # 6 p. 282 - 283
反应条件
potassium carbonate in 1,4-dioxane T=70°C; 16 h;
参考文献
Humphries, Paul S.; Balan, Gayatri; Bechle, Bruce M.; Conn, Edward L.; Dirico, Kenneth J.; Hui, Yu; Oliver, Robert M.; Southers, James A.; Yang, Xiaojing
Tetrahedron Letters, 2009 , vol. 50, # 18 p. 2140 - 2143
反应条件
oxygen; methylene blue in dichloromethane T=0°C; 12 h; Irradiation;
参考文献
Murata, Shigeru; Sugiyama, Kenji; Tomioka, Hideo
Journal of Organic Chemistry, 1993 , vol. 58, # 7 p. 1976 - 1984
反应条件
sodium hydrogencarbonate in water T=95°C; 24 h;
参考文献
Sarma, Koushik Das; Maitra, Uday
Tetrahedron, 1998 , vol. 54, # 19 p. 4965 - 4976
反应条件
oxygen; methylene blue in dichloromethane T=0°C; 12 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 58, # 7 p. 1976 - 1984
反应条件
1: methanol; homophthalic anhydride With 1,8-diazabicyclo[5.4.0]undec-7-ene T=20°C; 0.166667 h; 2: methyl iodide With 1,8-diazabicyclo[5.4.0]undec-7-ene in methanol T=20°C; chemoselective reaction;
参考文献
Jana, Amit Kumar; Karmakar, Raju; Dinda, Bidyut Kumar; Mitra, Prithiba; Ghosh, Ketaki; Karmakar, Rajdip; Mal, Dipakranjan
Journal of the Indian Chemical Society, 2012 , vol. 89, # 7 p. 975 - 979
反应条件
in methanol; sulfuric acid
参考文献
US8691968 B2, ;
Page/Page column ;
反应条件
1: 2-(2-Carboxyphenyl)acetic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetone 0.166667 h; 2: methyl iodide in acetone T=20°C; 4 h;
参考文献
Synthetic Communications, , vol. 38, # 22 p. 3937 - 3946
