1-(2-氨乙基)吡咯烷合成路线 （共 28 条）
反应条件
in methanol
Ambient temperature;
参考文献
Iyengar; Sami; Remers; Bradner; Schurig
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 16 - 20
反应条件
N-ethyl-N,N-diisopropylamine in 1,4-dioxane
T=105°C; 48 h;
参考文献
Allergan, Inc.
Patent: US2007/32478 A1, 2007 ;
Location in patent: Page/Page column 146 ;
US 20070032478 A1
反应条件
in ethanol
2 h; Ambient temperature;
参考文献
Fernandez Brana; Martinez Sanz; Castellano; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 207 - 212
反应条件
in ethanol
2 h; Ambient temperature;
参考文献
Fernandez Brana; Martinez Sanz; Castellano; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 207 - 212
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 0 deg C, 30 min, 2.) room temp.; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: With methanol; sodium cyanoborohydride; acetic acid
T=20°C; 2 h;
2: With sodium hydrogencarbonate in methanol; water
参考文献
Allergan, Inc.
Patent: US2007/32478 A1, 2007 ;
Location in patent: Page/Page column 91 ;
US 20070032478 A1
参考文献
He, Lingyan; Zhang, Liang; Liu, Xiaofeng; Li, Xianghua; Zheng, Mingyue; Li, HongLin; Yu, Kunqian; Chen, Kaixian; Shen, Xu; Jiang, Hualiang; Liu, Hong
Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2465 - 2481
反应条件
in toluene
2 h; Heating;
参考文献
Zee-Cheng; Cheng
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1216 - 1222
