2,4-二氨基-6-硝基喹唑啉合成路线 （共 8 条）
反应条件
sodium methylate in methanol T=100°C; P=11251.1 Torr; 0.25 h; Microwave irradiation;
参考文献
Tomasic, Tihomir; Zidar, Nace; Rupnik, Veronika; Kovac, Andreja; Blanot, Didier; Gobec, Stanislav; Kikelj, Danijel; Masic, Lucija Peterlin
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 153 - 157
反应条件
in methanol; ethanol T=20°C; 5 h; Heating / reflux;
参考文献
US2005/20833 A1, ;
Page 4 ;
反应条件
1: guanidine Carbonate With sodium methylate in methanol 0.5 h; Heating / reflux; 2: 1-amino-2-cyano-4-nitrobenzene in methanol 24 h; Heating / reflux;
参考文献
US2003/191139 A1, ;
Page/Page column 23 ;
反应条件
1: 75 percent / H2 / Pd/C 2: 64 percent / HNO2; CuCN View Scheme
参考文献
Graffner-Nordberg, Malin; Sjoedin, Karin; Tunek, Anders; Hallberg, Anders
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 591 - 601
反应条件
1: 75 percent / H2 / Pd/C 2: 64 percent / HNO2; CuCN 3: 62 percent / HCOOH / Ra-Ni / 1.5 h / 80 °C View Scheme
参考文献
Graffner-Nordberg, Malin; Sjoedin, Karin; Tunek, Anders; Hallberg, Anders
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 591 - 601
反应条件
hydrogenchloride; tin(ll) chloride
T=4°C; 24 h;
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
反应条件
1: H2 / Raney Ni / dimethylformamide / 3 h / 1810.02 Torr / Ambient temperature
2: AcOH
3: H2, AcOH / Raney Ni / 7 h / 1810.02 Torr / Ambient temperature
View Scheme
参考文献
Gangjee, Aleem; Vidwans, Anup P.; Vasudevan, Anil; Queener, Sherry F.; Kisliuk, Roy L.; Cody, Vivian; Li, Ruming; Galitsky, Nikolai; Luft, Joe R.; Pangborn, Walter
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3426 - 3434
反应条件
1: 75 percent / H2 / Pd/C
2: 64 percent / HNO2; CuCN
3: 62 percent / HCOOH / Ra-Ni / 1.5 h / 80 °C
4: 81 percent / NaBH4 / methanol / 20 °C
View Scheme
参考文献
Graffner-Nordberg, Malin; Sjoedin, Karin; Tunek, Anders; Hallberg, Anders
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 591 - 601
