4-环己基-3-丁烯-2-酮合成路线 （共 15 条）
反应条件
1: With sodium in methanol T=80°C; 4 h; 2: With sodium hydroxide in methanol; water T=80°C; 0.666667 h; 3: With hydrogenchloride in methanol; water Reflux;
参考文献
WO2011/62964 A1, ;
Page/Page column 18 ;
反应条件
1: EtONa / ethanol / 6 h / Heating 2: 2 N NaOH / 2 h / Heating 3: 5 N H2SO4 / 4.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 19 p. 3429 - 3447
反应条件
sodium hydroxide in water
T=7°C; 2.5 h;
参考文献
UNIVERSITY OF ROCHESTER; SOUTHERN RESEARCH INSTITUTE; GOLDFARB, David, S.; MADDRY, Joseph, A.; RASMUSSEN, Lynn; WHITE, Ellie, Lucile; WENNERBERG, Krister
Patent: WO2011/62964 A1, 2011 ;
Location in patent: Page/Page column 17 ;
反应条件
1: With sodium hydroxide in water
T=100°C; 0.05 - 0.25 h;
2: With acetic acid in water
Product distribution / selectivity;
参考文献
Barnicki, Scott Donald; McCusker-Orth, Jennifer Ellen; Miller, Jerry Lynn
Patent: US2005/4401 A1, 2005 ;
Location in patent: Page 17 ;
反应条件
L-proline in dimethyl sulfoxide
T=-20°C; P=1500150 Torr; 72 h;
参考文献
Hayashi, Yujiro; Tsuboi, Wataru; Shoji, Mitsuru; Suzuki, Noriyuki
Tetrahedron Letters, 2004 , vol. 45, # 22 p. 4353 - 4356
反应条件
in dichloromethane
Reflux;
参考文献
Sawada, Masato; Kubo, Shin-Ichiro; Matsumura, Koji; Takemoto, Yasushi; Kobayashi, Hiroki; Tashiro, Etsu; Kitahara, Takeshi; Watanabe, Hidenori; Imoto, Masaya
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1385 - 1389
反应条件
L-proline in various solvent(s)
T=20°C; 25 h; Title compound not separated from byproducts;
参考文献
Loh, Teck-Peng; Feng, Li-Chun; Yang, Hai-Yan; Yang, Jian-Ying
Tetrahedron Letters, 2002 , vol. 43, # 48 p. 8741 - 8743
反应条件
sodium hydroxide; acetone
参考文献
Kon
Journal of the Chemical Society, 1926 , p. 1799
参考文献
Cuvigny,T.; Normant,H.
Bulletin de la Societe Chimique de France, 1960 , p. 515 - 521
参考文献
Kon
Journal of the Chemical Society, 1926 , p. 1799
