3-甲氧基-4-甲基苯甲酸合成路线 （共 34 条）
反应条件
azobisisobutyronitrile in thionyl chloride; trichloromonobromomethane; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US6620837 B1, 2003 ;
US 6620837 B1
反应条件
sulfuric acid in dichloromethane 16 h;
参考文献
ICI AMERICAS INC.
Patent: EP242167 B1, 1991 ;
反应条件
1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 25 - 35 °C 2: 2,2'-azo-bisisobutyronitrile; 1,3-dibromo-5,5-dimethyl-hydantoin / chloroform / 60 - 65 °C 3: silver(l) oxide / 1,4-dioxane / 20 - 100 °C View Scheme
参考文献
Srinivas, Keesari; Srinivasan, Neti; Krishna, Muddasani Rama; Reddy, Chinta Raveendra; Arunagiri, Muthulingam; Lalitha, Routhu; Reddy, Kikkura Sri Rami; Reddy, Bijjula Sreenivasa; Reddy, Ghanta Mahesh; Reddy, Padi Pratap; Kumar, Muppa Kishore; Reddy, Manne Satyanaraya
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 952 - 954
反应条件
(i) SOCl2, (ii) Li<AlH(OtBu)3>; Multistep reaction;
参考文献
Irie; Matsumoto; Nishimura; Zhang
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 7 p. 1852 - 1856
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; 2,2'-azo-bisisobutyronitrile in chloroform
4 h; Reflux;
参考文献
Srinivas, Keesari; Srinivasan, Neti; Krishna, Muddasani Rama; Reddy, Chinta Raveendra; Arunagiri, Muthulingam; Lalitha, Routhu; Reddy, Kikkura Sri Rami; Reddy, Bijjula Sreenivasa; Reddy, Ghanta Mahesh; Reddy, Padi Pratap; Kumar, Muppa Kishore; Reddy, Manne Satyanaraya
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 952 - 954
反应条件
1: thionyl chloride / 2 h / Heating
2: 100 percent / diisopropylethylamine / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Wang, Bowei; Vernier, Jean-Michel; Rao, Sara; Chung, Janice; Anderson, Jeffery J.; Brodkin, Jesse D.; Jiang, Xiaohui; Gardner, Michael F.; Yang, Xiaoqing; Munoz, Benito
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 17 - 21
参考文献
ICI Americas Inc.
Patent: US4499299 A1, 1985 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 22°C; 12 h;
参考文献
Majetich, George; Hicks, Rodgers; Zhang, Yong; Tian, Xinrong; Feltman, Terry Lee; Fang, Jing; Duncan Jr., Sam
Journal of Organic Chemistry, 1996 , vol. 61, # 23 p. 8169 - 8185
反应条件
1: LiAlH4
2: SOCl2
View Scheme
参考文献
ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
WO 2011/156518 A2
反应条件
pyridinium chlorochromate in tetrahydrofuran
参考文献
Abbott Laboratories
Patent: US5128362 A1, 1992 ;
