1,5-二氯-2-甲基-4-硝基苯合成路线 (共 7 条)
反应条件
sodium hydroxide; nickel T=125 - 135°C; P=36775.4 - 73550.8 Torr; Hydrogenation;
参考文献
Farbenfabr. Bayer
Patent: DE812075 , 1950 ;
DRP/DRBP Org.Chem.
反应条件
ammonia in water; isopropyl alcohol T=120°C; 6 h;
参考文献
Wollweber; Kolling; Niemers; et al.
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 5 p. 531 - 542
参考文献
Gen. Aniline and Film Corp.
Patent: US2581972 , 1948 ;
DRP/DRBP Org.Chem.
Full Text Show Details
Gen. Aniline and Film Corp.
Patent: DE847598 , 1949 ;
参考文献
Cohen; Dakin
Journal of the Chemical Society, 1902 , vol. 81, p. 1335
Journal of the Chemical Society, 1906 , vol. 89, p. 1454
反应条件
sulfuric acid; nitric acid
T=-10°C;
参考文献
BIORELIX PHARMACEUTICALS, INC.; DIXON, Brian, R.; BLOUNT, Kenneth, F.; BERMAN, Judd; COISH, Philip, D.G.; OSTERMAN, David; HARPREET, Kaur; KELLS, Kevin; WICKENS, Phil; WILSON, Jeffrey; WU, Justin
Patent: WO2010/19208 A1, 2010 ;
Location in patent: Page/Page column 177 ;
反应条件
Diazotization.Behandlung der Diazoniumloesung mit CuCl;
参考文献
Cohen; Dakin
Journal of the Chemical Society, 1902 , vol. 81, p. 1335
Journal of the Chemical Society, 1906 , vol. 89, p. 1454
反应条件
Diazotization.Behandeln mit Kupfer(I)-chlorid in Salzsaeure;
参考文献
Dadswell; Kenner
Journal of the Chemical Society, 1927 , p. 586