3,4-(亚甲二氧基)甲苯合成路线 （共 45 条）
反应条件
phosphorus pentoxide in 1,2-dichloro-ethane T=20°C; Friedel-Crafts-acylation; 16 h;
参考文献
Grasso, Silvana; De Sarro, Giovambattista; De Sarro, Angela; Micale, Nicola; Zappala, Maria; Puja, Giulia; Baraldi, Mario; De Micheli, Carlo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2851 - 2859
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
Journal of Organic Chemistry, , vol. 78, # 11 p. 5264 - 5272
反应条件
nitric acid in chloroform
参考文献
MITSUBISHI TANABE PHARMA CORPORATION
Patent: US2012/196824 A1, 2012 ;
反应条件
bromine; dibenzoyl peroxide
参考文献
Sumitomo Chemical Company, Limited
Patent: US4335263 A1, 1982 ;
反应条件
hydrogenchloride; tetrabutylammomium bromide in dichloromethane; water
参考文献
Given, Bruce D.; Dixon, Richard A.F.
Patent: US2008/85313 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
hydrogenchloride; formaldehyd in hexane; water
参考文献
Texas Biotechnology Corporation
Patent: US6432994 B1, 2002 ;
US 6432994 B1
反应条件
hydrogenchloride; formaldehyd in hexane; dichloromethane; water
参考文献
Texas Biotechnology Corp.
Patent: US6248767 B1, 2001 ;
反应条件
hydrogenchloride; formaldehyd; tetrabutylammomium bromide in hexane; dichloromethane; water
参考文献
Texas Biotechnology Corporation
Patent: US5783705 A1, 1998 ;
反应条件
hydrogenchloride; formaldehyd; tetrabutylammomium bromide in water
参考文献
ENCYSIVE PHARMACEUTICALS, INC.
Patent: WO2007/106494 A2, 2007 ;
Location in patent: Page/Page column 39 ;
反应条件
1: in hydrogenchloride; diethyl ether T=0 - 20°C; 12 h; 2: in hexane Heating;
参考文献
Wu, Chengde; Chan, Ming F.; Stavros, Fiona; Raju; Okun, Ilya; Mong, Seymour; Keller, Karin M.; Brock, Tommy; Kogan, Timothy P.; Dixon, Richard A. F.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1690 - 1697
