tetrahydrofuran T=65°C; 12 h;

1: sodium borohydride / methanol / 1.5 h / 0 °C 2: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C 3: diethyl ether; xylene / 48 h / 100 °C 4: 45.8 percent / butylene oxide / 12 h / 65 °C View Scheme

1: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C 2: diethyl ether; xylene / 48 h / 100 °C 3: 45.8 percent / butylene oxide / 12 h / 65 °C View Scheme

1: diethyl ether; xylene / 48 h / 100 °C 2: 45.8 percent / butylene oxide / 12 h / 65 °C View Scheme

Multistep reaction;