乙基-4-((E)-2-(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)-1-丙烯基)苯甲酸合成路线 （共 10 条）
反应条件
potassium hydroxide; water
参考文献
WISCONSIN ALUMNI RESEARCH FOUNDATION
Patent: WO2007/5568 A1, 2007 ;
Location in patent: Page/Page column 11 ;
WO 2007/005568 A1
反应条件
1: diethyl p-carboxyethylbenzylphosphonate With dimsyl sodium
0.5 h;
2: 1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone in dimethyl sulfoxide
4 h;
3: sodium ethanolate in ethanol; dimethyl sulfoxide
参考文献
WISCONSIN ALUMNI RESEARCH FOUNDATION
Patent: WO2007/5568 A1, 2007 ;
Location in patent: Page/Page column 10-11 ;
WO 2007/005568 A1
反应条件
tetrahydrofuran
T=65°C; 12 h;
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
反应条件
1: sodium borohydride / methanol / 1.5 h / 0 °C
2: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C
3: diethyl ether; xylene / 48 h / 100 °C
4: 69.3 percent / butylene oxide / 12 h / 65 °C
View Scheme
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
反应条件
1: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C
2: diethyl ether; xylene / 48 h / 100 °C
3: 69.3 percent / butylene oxide / 12 h / 65 °C
View Scheme
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
反应条件
1: diethyl ether; xylene / 48 h / 100 °C
2: 69.3 percent / butylene oxide / 12 h / 65 °C
View Scheme
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
反应条件
dimsyl sodium; sodium ethanolate
1. DMSO/4 h 2. 2. 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Dawson; Derdzinski; Hobbs; et al.
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5265 - 5267
参考文献
Hoffmann-La Roche
Patent: DE2854354 , 1979 ;
Chem.Abstr., 1979 , vol. 91, # 140631
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
T=0 - 5°C;
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
反应条件
1: 89 percent / lithium aluminum hydride / tetrahydrofuran; diethyl ether / 0 - 5 °C
2: 1.) sodium hydride / 1.) DMF, rt, 1h; 2.) rt, 2 h
View Scheme
参考文献
Hoffmann-La Roche
Patent: DE2854354 , 1979 ;
Chem.Abstr., 1979 , vol. 91, # 140631
