(3Z,6Z)-3-[(5-叔丁基-1H-咪唑-4-基)亚甲基]-6-(苯亚甲基)-2,5-哌嗪二酮合成路线 （共 11 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=80°C; 2.5 - 5 h; Heating / reflux; Product distribution / selectivity;
参考文献
Palladino, Michael A.; Lloyd, George Kenneth; Hayashi, Yoshio
Patent: US2008/221122 A1, 2008 ;
Location in patent: Page/Page column 20; 28 ;
反应条件
esterase enzyme T=37°C; pH=7.4; Aqueous phosphate bufferEnzymatic reaction;
参考文献
WO2012/35436 A1, ;
Page/Page column 48 ;
反应条件
esterase enzyme T=37°C; pH=7.4; Aqueous phosphate bufferEnzymatic reaction;
参考文献
WO2012/35436 A1, ;
Page/Page column 49 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=80°C; 14 h; Product distribution / selectivity;
参考文献
Palladino, Michael A.; Lloyd, George Kenneth; Hayashi, Yoshio
Patent: US2008/221122 A1, 2008 ;
Location in patent: Page/Page column 20 ;
反应条件
1: sodium L-ascorbate; CuSO4‵5H2O / N,N-dimethyl-formamide; water; tert-butyl alcohol / 0.17 h / 80 °C / Microwave irradiation 2: an ion exchange resin / acetonitrile; water / 20 °C 3: esterase enzyme / 37 °C / pH 7.4 / Aqueous phosphate buffer; Enzymatic reaction View Scheme
反应条件
1: thionyl chloride / chloroform / 3 h / 20 °C / Reflux 2: water / 3.5 h / 150 °C / Sealed tube 3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C 4: manganese(IV) oxide / acetone / 4 h / 20 °C 5: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere 6: caesium carbonate View Scheme
反应条件
1: manganese(IV) oxide / acetone / 4 h / 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere 3: caesium carbonate View Scheme
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C 2: manganese(IV) oxide / acetone / 4 h / 20 °C 3: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere 4: caesium carbonate View Scheme
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere 2: caesium carbonate View Scheme
反应条件
1: water / 3.5 h / 150 °C / Sealed tube 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C 3: manganese(IV) oxide / acetone / 4 h / 20 °C 4: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere 5: caesium carbonate View Scheme
