N-叔丁氧羰基-(4-氨基甲基苯基)乙酸合成路线 （共 12 条）
反应条件
1: With sodium hydroxide in 1,4-dioxane; water 24 h; 2: With citric acid in water
参考文献
WO2007/28083 A2, ;
Page/Page column 116 ;
WO 2007/028083 A2
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; Cooling with ice;
参考文献
EP2439204 A1, ;
Page/Page column 60 ;
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1894 - 1908
反应条件
1: SOCl2, Py / toluene; dimethylformamide / 0.08 h / 0 °C 2: Et3N, DMAP / CH2Cl2 / Ambient temperature 3: 98 percent / NaN3 / dimethylformamide / Ambient temperature 4: 23 percent / H2 / 10percent Pd/C / methanol / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1894 - 1908
反应条件
1: Et3N, DMAP / CH2Cl2 / Ambient temperature 2: 98 percent / NaN3 / dimethylformamide / Ambient temperature 3: 23 percent / H2 / 10percent Pd/C / methanol / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1894 - 1908
反应条件
1: 98 percent / NaN3 / dimethylformamide / Ambient temperature 2: 23 percent / H2 / 10percent Pd/C / methanol / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1894 - 1908
反应条件
lithium hydroxide in tetrahydrofuran T=25°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2647 - 2652
反应条件
1: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 2: Et3N / tetrahydrofuran / 25 °C 3: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2647 - 2652
反应条件
1: dimethylformamide / Heating 2: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 3: Et3N / tetrahydrofuran / 25 °C 4: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2647 - 2652
反应条件
1: H2SO4 / Heating 2: dimethylformamide / Heating 3: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 4: Et3N / tetrahydrofuran / 25 °C 5: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2647 - 2652
