Boc-β-氯-L-丙氨酸合成路线 （共 4 条）
反应条件
sodium hydroxide in 1,4-dioxane; water 1.) 0 deg C, 15 min, 2.) RT, 2 h;
参考文献
Cheung, Kam Sing; Wasserman, Steven A.; Dudek, Edward; Lerner, Stephen A.; Johnston, Michael
Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1733 - 1741
反应条件
triethylamine in aqueous 1,4-dioxane; water
参考文献
University of Florida
Patent: US4888427 A1, 1989 ;
反应条件
1: 93 percent / 1-ethyl-3-<3-(dimethylamino)propyl>-carbodiimide / CH2Cl2 / 15 h / Ambient temperature 2: 1.) sodium iodide, 2.) 60percent sodium hydride in mineral oil / 1.) dimethylformamide, 0 deg C, 30 min, 2.) dimethylformamide, 0 deg C, 15 min; room temperature, 90 min 3: hydrogen / 10percent Pd/C / methanol / 24 h View Scheme
参考文献
Baldwin, Jack E.; Adlington, Robert M.; Mellor, Lisa C.
Tetrahedron, 1994 , vol. 50, # 17 p. 5049 - 5066
反应条件
1: 83 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride / H2O / pH 4-5
2: 88 percent / NaH / CH2Cl2 / 12 h / 50 °C
View Scheme
参考文献
Miller; Mattingly; Morrison; Kerwin Jr.
Journal of the American Chemical Society, 1980 , vol. 102, # 23 p. 7026 - 7032
