5-氯-2-羟基苯甲酰胺合成路线 （共 26 条）
反应条件
ammonia T=20°C; 48 h;
参考文献
Kim, Jihye; Kang, Sookjin; Hong, Sungchae; Yum, Soowhan; Kim, Young Mi; Jung, Yunjin
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 36 - 44
反应条件
1: With ammonia in methanol T=20°C; P=760.051 Torr; 18 - 24 h; Heating / reflux; 2: With hydrogenchloride in methanol; water T=4°C; pH=~ 4;
参考文献
US2003/216593 A1, ;
Page/Page column 7-8 ;
反应条件
in ethanol; water T=35 - 37°C; 18 h; rat liver microsomes, pH 7.4; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 53, # 17 p. 4112 - 4114
反应条件
in ethanol; water T=35 - 37°C; 18 h; rat liver microsomes, pH 7.4; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 53, # 17 p. 4112 - 4114
反应条件
1: toluene / 3 h / 100 - 105 °C 2: H2O / 5 - 10 °C 3: 49 percent Chromat. / ethanol; H2O / 18 h / 35 - 37 °C / rat liver microsomes, pH 7.4 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 17 p. 4112 - 4114
反应条件
in ethanol; water T=35 - 37°C; 18 h; rat liver microsomes, pH 7.4; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 53, # 17 p. 4112 - 4114
反应条件
in ethanol; water T=35 - 37°C; 18 h; rat liver microsomes, pH 7.4; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 53, # 17 p. 4112 - 4114
反应条件
ammonium hydroxide in tetrahydrofuran Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 4 p. 734 - 745
反应条件
1: 0.5 h / Heating 2: oxalyl chloride / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature 3: conc. aq. NH3 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 4 p. 734 - 745
反应条件
1: oxalyl chloride / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature 2: conc. aq. NH3 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 4 p. 734 - 745
