反应条件
1: 1.) DEAD, p-NO2-C6H4COOH, PPh3, 2.) aq. 2N NaOH / 1.) THF,0 deg C, 30 min; 2.) THF-MeOH, 0 deg C, 1h 2: imidazole / dimethylformamide 3: 1.) nBu3SnH, LDA, 2.) I2 / 1.) THF, 0 deg C, 3 h; 2.) Et2O, 0 deg C, 30 min 4: 1.) disiamylborane, 2.) aq. 2N NaOH, Pd(PPh3)4 / 1.) THF,0 deg C, 1h; 2.) 50 deg C, 16 h 5: 80 percent / nBu4NF / tetrahydrofuran / 18 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 47 p. 5849 - 5852
