1-乙基-1,2,3,4-四氢喹啉-7-醇合成路线 （共 4 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 1 h; 2: With sodium hydrogencarbonate in water
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/16934 A1, 2005 ;
Location in patent: Page/Page column 12-13 ;
反应条件
sodium hydrogencarbonate; tetrabutylammomium bromide in water
T=0 - 20°C; 12 h;
参考文献
UNIVERSITY OF MASSACHUSETTS
Patent: WO2009/36351 A2, 2009 ;
Location in patent: Page/Page column 13-14; 13/24 ;
反应条件
1: With sodium tetrahydroborate
T=20°C; 2 h; Inert atmosphere;
2: With acetaldehyde
T=20°C; Inert atmosphere;
参考文献
Anzalone, Andrew V.; Wang, Tracy Y.; Chen, Zhixing; Cornish, Virginia W.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 2 p. 650 - 654
Angew. Chem., 2013 , vol. 125, # 2 p. 678 - 682,5
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / |Inert atmosphere; |Cooling with ice; |Reflux
2.1: sodium tetrahydroborate / 2 h / 20 °C / |Inert atmosphere
2.2: 20 °C / |Inert atmosphere
View Scheme
参考文献
Anzalone, Andrew V.; Wang, Tracy Y.; Chen, Zhixing; Cornish, Virginia W.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 2 p. 650 - 654
Angew. Chem., 2013 , vol. 125, # 2 p. 678 - 682,5
