6-(苄氧基)-1-己醇合成路线 （共 26 条）
反应条件
N-bromosuccinmide; triphenylphosphine in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Tsuda; Hosoi; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 1 p. 18 - 22
反应条件
1: 51 percent / mercury(II) cyanide / nitromethane / 20 h / 21 °C 2: 97 percent / hydrogen / palladium-charcoal / ethanol / 4.5 h / 2280 Torr 3: 82 percent / pyridinium chlorochromate / CH2Cl2 / 0.83 h 4: 1.) sodium hydride / 1.) tetrahydrofuran, 10 min, 2.) 5 min 5: 95 percent / hydrogen / palladium-charcoal / ethanol / 1 h View Scheme
参考文献
Collins, Peter M.; Eder, Hansjoerg
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1525 - 1530
反应条件
1: 88 percent / N-bromosuccinimide, triphenylphosphine / tetrahydrofuran / 2 h / Ambient temperature 2: 75 percent / 2 h / 140 °C 3: 1.) potassium tert-butoxide / 1.) THF-DMSO, 2.) r.t., occasional sonication, 50 min 4: 93 percent / hydrogen / 10 percent Pd-C / ethanol / 24 h / 2942.03 Torr / Ambient temperature View Scheme
参考文献
Tsuda; Hosoi; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 1 p. 18 - 22
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.5 h; Inert atmosphere; 2: With triethylamine in dichloromethane T=-78 - 0°C; 0.5 h; Inert atmosphere;
参考文献
Sudhakar, Gangarajula; Reddy, Karla Janardhan; Nanubolu, Jagadeesh Babu
Tetrahedron, 2013 , vol. 69, # 11 p. 2419 - 2429
反应条件
pyridine in chloroform T=0 - 20°C; 4 h;
参考文献
Colera, Manuel; Costero, Ana M.; Gavina, Pablo; Gil, Salvador
Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2673 - 2679
反应条件
1: 6-hydroxy-1-hexanol With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 20°C; 0.5 h;
2: benzyl bromide With tetrabutyl ammonium fluoride in tetrahydrofuran; mineral oil
T=20°C;
参考文献
Singh Yadav, Jhillu; Shiva Shankar, Kattela; Srinivas Reddy, Anugu; Subba Reddy, Basi V.
Helvetica Chimica Acta, 2014 , vol. 97, # 4 p. 546 - 555
反应条件
water; 2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane
T=20°C; Product distribution / selectivity;
参考文献
The University of Mississipi
Patent: WO2005/100329 A1, 2005 ;
Location in patent: Page/Page column 29; 31; 47 ;
反应条件
sodium
T=80°C; 15 h;
参考文献
Quici, Silvio; Manfredi, Amedea; Raimondi, Laura; Sironi, Angelo
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6379 - 6388
反应条件
1: 5-benzyloxy-1-pentanal; diazomethyl-trimethyl-silane With triphenylphosphine; isopropyl alcohol; Wilkinson's catalyst in tetrahydrofuran
T=20°C;
2: pyrocatecholborane in tetrahydrofuran
3: With NaBO3 in 1,4-dioxane; water
T=20°C; 3 h;
参考文献
Lebel, Helene; Ladjel, Chehla
Journal of Organometallic Chemistry, 2005 , vol. 690, # 23 p. 5198 - 5205
反应条件
NaBH(HFIP)3 in tetrahydrofuran; hexafluoroisopropyl alcohol
T=0°C; 2 h; chemoselective reaction;
参考文献
Kuroiwa, Yasutaka; Matsumura, Shuichi; Toshima, Kazunobu
Synlett, 2008 , # 16 p. 2523 - 2525
