1: With lithium; chloro-diphenylphosphine in tetrahydrofuran
2: With water; sodium hydroxide in tetrahydrofuran; diethyl ether
3: With hydrogenchloride in water
Cooling with ice;
参考文献
PFIZER INC.; Brodney, Michael Aaron; Efremov, Ivan Viktorovich; Helal, Christopher John; O'Neill, Brian Thomas
Patent: US2013/150376 A1, 2013 ;
Location in patent: Paragraph 0294 ;
