2-甲基-联苯-2-羧酸合成路线 （共 19 条）
反应条件
ethylenediaminetetraacetic acid; potassium carbonate; palladium dichloride
T=100°C; Suzuki-Miyaura reaction; 3 h;
参考文献
Korolev, Dmitrii N.; Bumagin, Nikolay A.
Tetrahedron Letters, 2005 , vol. 46, # 34 p. 5751 - 5754
反应条件
1: With palladium diacetate in N,N-dimethyl-formamide
T=60°C; Addition; 3 h;
2: With hydrogenchloride in N,N-dimethyl-formamide
T=20°C; Hydrolysis;
参考文献
Xia, Min; Chen, Zhenchu
Synthetic Communications, 2000 , vol. 30, # 1 p. 63 - 68
反应条件
potassium hydroxide in ethanol
0.5 h; Heating;
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
potassium hydroxide in ethanol
1 h; Heating;
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
sodium methylate in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene
1.5 h; Heating;
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
sodium hydroxide in ethanol
18 h; Ambient temperature;
参考文献
Matsuhisa, Akira; Tanaka, Akihiro; Kikuchi, Kazumi; Shimada, Yoshiaki; Yatsu, Takeyuki; Yanagisawa, Isao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 11 p. 1870 - 1874
反应条件
pyridine
T=270°C; Erwaermen des erhaltenen 2'-Methyl-biphenyl-carbonitrils-(2) mit Schwefelsaeure;
参考文献
Orchin; Woolfolk
Journal of the American Chemical Society, 1945 , vol. 67, p. 122
反应条件
1: 80 percent
2: 2. NaOH; 3.) HCl
View Scheme
参考文献
Dorra, Michael; Gomann, Klaus; Guth, Michael; Kirmse, Wolfgang
Journal of Physical Organic Chemistry, 1996 , vol. 9, # 9 p. 598 - 610
反应条件
1: 73 percent / triluoroacetic anhydride / 4 h / Ambient temperature
2: 96 percent / diethyl ether; benzene / 1.) RT, 20 h, 2.) reflux, 1 h
3: 95 percent / NaOCH3 / hexamethylphosphoric acid triamide; toluene / 1.5 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
hydrogenchloride
60 h; Heating;
参考文献
Ohkawa, Takehiko; Zenkoh, Tatsuya; Tomita, Masayuki; Hosogai, Naomi; Hemmi, Keiji; Tanaka, Hirokazu; Setoi, Hiroyuki
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 4 p. 501 - 510
