2,2,2-三氟-4-甲氧基乙酰苯合成路线 （共 42 条）
反应条件
1: 80 percent / tetrahydrofuran / 1 h / -78 °C 2: 100 percent / KOH / ethanol / 20 °C 3: 85 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2 View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8565 - 8571
反应条件
1: 100 percent / KOH / ethanol / 20 °C 2: 85 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2 View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8565 - 8571
反应条件
1.1: tetrahydrofuran / 0.17 h / 0 °C / |Inert atmosphere; |Sealed tube 1.2: 0 - 20 °C / |Inert atmosphere; |Sealed tube 1.3: 0 - 20 °C / |Inert atmosphere; |Sealed tube 2.1: oxoammonium salt; 2,6-dimethylpyridine / dichloromethane / 20 °C / |Sealed tube View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 18 p. 8131 - 8141
反应条件
1.1: cesium fluoride / toluene / 0.17 h / 0 °C 1.2: 24 h / 0 - 20 °C 2.1: tetrabutyl ammonium fluoride; water / toluene; tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 48, # 77 p. 9610 - 9612
反应条件
1.1: pyridine / dichloromethane / 0 - 20 °C 2.1: cesium fluoride / toluene / 0.17 h / 0 °C 2.2: 24 h / 0 - 20 °C 3.1: tetrabutyl ammonium fluoride; water / toluene; tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 48, # 77 p. 9610 - 9612
反应条件
1.1: N-bromosuccinmide; AlCl3, aluminium chloride / dichloromethane / 5 h / -78 - 20 °C / |Inert atmosphere 2.1: magnesium / tetrahydrofuran / 2.5 h / |Inert atmosphere; |Reflux 2.2: 2.08 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 19, # 21 p. 6551 - 6555
反应条件
T=0°C; 8 h; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 56, # 2 p. 215 - 237
反应条件
n-butyllithium 2) ether, -78 deg C to room temperature; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 56, # 2 p. 893 - 896
反应条件
(i) Mg, (ii) /BRN= 742035/; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 25, p. 473 - 474
反应条件
MnI2 1.) ether, 0 deg C, 10 min; room temp., 30 min, 2.) ether, room temp., 2 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 1 p. 37 - 40
