2,2,2-三氟-4-甲氧基乙酰苯合成路线 （共 42 条）
反应条件
1: 1-bromo-4-methoxy-benzene With iodine; magnesium in tetrahydrofuran 2 h; Heating; 2: N-(trifluoroacetyl)piperidine T=0 - 20°C; 2 h;
参考文献
Schenck, Hilary A.; Lenkowski, Paul W.; Choudhury-Mukherjee, Indrani; Ko, Seong-Hoon; Stables, James P.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 979 - 993
反应条件
in water; ethyl acetate
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
in tetrahydrofuran T=-5 - 20°C; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2004/14870 A1, 2004 ;
Location in patent: Page 44-46 ;
反应条件
1: trifluoroacetic acid With bromine; magnesium in diethyl ether T=20°C; Metallation; 1.5 h; 2: 4-methoxyphenyl magnesium bromide in diethyl ether Grignard reaction; 1 h; Heating;
参考文献
Uno, Hidemitsu; Nibu, Nobumasa; Misobe, Noboru
Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 6 p. 1365 - 1375
反应条件
in tetrahydrofuran T=-78°C; 1 h;
参考文献
Konno, Tsutomu; Takehana, Tsuyoshi; Mishima, Makoto; Ishihara, Takashi
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3545 - 3550
反应条件
Triethylgermyl-natrium in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=-60°C; 1.5 h;
参考文献
Yokoyama, Yasuo; Mochida, Kunio
Synlett, 1997 , vol. 1997, # 8 p. 907 - 908
反应条件
magnesium in diethyl ether
反应条件
4-(N,N-dimethlyamino)pyridine; AlCl3, aluminium chloride in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Segawa, Yukari; Higashihara, Tomoya; Ueda, Mitsuru
Journal of the American Chemical Society, 2010 , vol. 132, # 32 p. 11000 - 11001
反应条件
tributylphosphine; palladium diacetate in 1-methyl-pyrrolidin-2-one T=80°C; 4 h;
参考文献
Kakino; Shimizu; Yamamoto
Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 2 p. 371 - 376
反应条件
hydrogenchloride in tetrahydrofuran
