1,4-二氢-7-甲氧基-4-氧代-3-喹啉甲腈合成路线 （共 8 条）
参考文献
American Home Products Corporation
Patent: US2003/65180 A1, 2003 ;
反应条件
in diphenylether
Heating;
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
in diphenylether; biphenyl
T=256°C; 6 h;
参考文献
Wyeth
Patent: EP1268487 B1, 2003 ;
Location in patent: Page/Page column 68 ;
反应条件
T=140°C; 22.5 h; Neat (no solvent)Heating / reflux;
参考文献
Wyeth Holdings Corporation
Patent: EP1117659 B1, 2003 ;
Location in patent: Page 49 ;
反应条件
1: in tetrahydrofuran
T=-78°C;
2: With acetic acid
T=20°C;
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1.1: Heating
2.1: tetrahydrofuran / -78 °C
2.2: AcOH / 20 °C
View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
trichlorophosphate
Heating;
参考文献
Wyeth Holdings Corporation
Patent: EP1117659 B1, 2003 ;
Location in patent: Page 56 ;
反应条件
in tetrahydrofuran; ethyl acetate
参考文献
American Cyanamid Company
Patent: US6288082 B1, 2001 ;
