8-甲氧基-4-氧代-1,4-二氢喹啉-3-甲酸乙酯合成路线 （共 8 条）
反应条件
1.1: sodium hydroxide / water / 3 h / Reflux 2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 2.2: 4 h / 20 °C / Inert atmosphere 3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere View Scheme
参考文献
Pasquini, Serena; De Rosa, Maria; Pedani, Valentina; Mugnaini, Claudia; Guida, Francesca; Luongo, Livio; De Chiaro, Maria; Maione, Sabatino; Dragoni, Stefania; Frosini, Maria; Ligresti, Alessia; Di Marzo, Vincenzo; Corelli, Federico
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5444 - 5453
反应条件
sodium hydroxide in water 3 h; Reflux;
参考文献
Pasquini, Serena; De Rosa, Maria; Pedani, Valentina; Mugnaini, Claudia; Guida, Francesca; Luongo, Livio; De Chiaro, Maria; Maione, Sabatino; Dragoni, Stefania; Frosini, Maria; Ligresti, Alessia; Di Marzo, Vincenzo; Corelli, Federico
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5444 - 5453
反应条件
trichlorophosphate T=90°C; 16 h;
参考文献
HIGH POINT PHARMACEUTICALS, LLC; GADDAM, Bapu; POLISETTI, Dharma Rao; GUZEL, Mustafa; VICTORY, Samuel; KOSTURA, Matthew
Patent: WO2011/22216 A1, 2011 ;
Location in patent: Page/Page column 28 ;
WO 2011/022216 A1
反应条件
in diphenylether
T=90°C; 8 h; Reflux;
参考文献
HIGH POINT PHARMACEUTICALS, LLC; GADDAM, Bapu; POLISETTI, Dharma Rao; GUZEL, Mustafa; VICTORY, Samuel; KOSTURA, Matthew
Patent: WO2011/22216 A1, 2011 ;
Location in patent: Page/Page column 27-28 ;
WO 2011/022216 A1
反应条件
Eaton's reagent
T=90 - 100°C; Inert atmosphere;
参考文献
Mistry, Shailesh N.; Valant, Celine; Sexton, Patrick M.; Capuano, Ben; Christopoulos, Arthur; Scammells, Peter J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5151 - 5172
反应条件
1: 1 h / Heating
2: various solvent(s) / 1 h / Heating
View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
in diphenylether
T=120 - 250°C; aza-Michael type reaction; 0.333333 h; Microwave irradiationclosed vessel;
参考文献
Albrecht, Markus; Osetska, Olga; Rantanen, Toni; Froehlich, Roland; Bolm, Carsten
Synlett, 2010 , # 7 p. 1081 - 1084
反应条件
1: 100 - 120 °C
2: Eaton's reagent / 90 - 100 °C / |Inert atmosphere
View Scheme
参考文献
Mistry, Shailesh N.; Valant, Celine; Sexton, Patrick M.; Capuano, Ben; Christopoulos, Arthur; Scammells, Peter J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5151 - 5172
