(S)-1,2-环氧基-3-苯氧基丙烷合成路线 （共 42 条）
反应条件
1: phenol With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.333333 h; 2: (S)-(+)-3-nitro-benzenesulfonic acid oxiranylmethyl ester in N,N-dimethyl-formamide T=0 - 20°C; 16 h;
参考文献
ARTESIAN THERAPEUTICS, INC.
Patent: WO2006/60122 A2, 2006 ;
Location in patent: Page/Page column 26 ;
WO 2006/060122 A2
反应条件
sodium hydroxide; N-benzyl-N,N,N-trimethyl-ammonium chloride in water; toluene T=0 - 20°C; 40.5 h;
参考文献
DAISO CO., LTD.
Patent: EP1508568 A1, 2005 ;
Location in patent: Page 4 ;
反应条件
1: phenol With sodium hydride in N,N-dimethyl-formamide T=0°C; Metallation; 2: (2S)-glycidyl 4-toluenesulfonate in N,N-dimethyl-formamide Alkylation;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/56544 A1, 2005 ;
Location in patent: Page/Page column 36 ;
WO 2005/056544 A1
反应条件
1: With air; 4-nitro-benzoic acid; (R,R)-((t-Bu)4-salen)Co(II) T=20°C; 24 h; 2: With sodium hydride; p-toluenesulfonyl chloride in tetrahydrofuran T=0 - 20°C; 5 h;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Carlone, Armando; Locatelli, Manuela; Melchiorre, Paolo; Sambri, Letizia
Organic Letters, 2004 , vol. 6, # 22 p. 3973 - 3975
反应条件
potassium tert-butylate in tetrahydrofuran T=0°C;
参考文献
Tetrahedron: Asymmetry, , vol. 3, # 2 p. 205 - 208
反应条件
tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide in water T=20 - 100°C; 1 h;
参考文献
WO2012/143874 A1, ;
Page/Page column 35 ;
反应条件
Jacobsen's (R,R)-(salen)Co(III) catalyst; air; acetic acid in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315
反应条件
water in dichloromethane; acetonitrile T=0 - 20°C; 48 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Zhu, Chengfeng; Yuan, Guozan; Chen, Xu; Yang, Zhiwei; Cui, Yong
Journal of the American Chemical Society, 2012 , vol. 134, # 19 p. 8058 - 8061
反应条件
2,2,2-trifluoro-1,1-bis(trifluoromethyl)ethanol; polystyrene-immobilized chiral Co-salen complex in tetrahydrofuran T=20°C; 24 h;
参考文献
Synthesis, , # 4 p. 583 - 589
反应条件
1: With 2,2,2-trifluoro-1,1-bis(trifluoromethyl)ethanol; chiral polymer-supported Co(salen) complex T=4 - 25°C; 6 h; 2: With potassium hydroxide in diethyl ether T=25°C; 3 h; Further stages.;
参考文献
Organic Letters, , vol. 1, # 8 p. 1245 - 1248
