1-[2-(4-氟苯基)乙基]哌嗪合成路线 （共 5 条）
反应条件
potassium hydroxide in ethanol T=120°C; 3 h;
参考文献
Bartl; Dlabac; Protiva
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 11 p. 3182 - 3189
反应条件
1.1: tetrahydrofuran; hexane / 0.17 h / 20 °C 1.2: 87 percent / tetrahydrofuran; hexane / 24 h / 20 °C 2.1: 95 percent / H2; Et3N / Pd(OH)2/C / ethanol / 7 h / 40 °C / 1500.15 - 3000.3 Torr View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 3 p. 746 - 757
反应条件
hydrogenchloride in water T=20 - 83°C; 6.5 h;
参考文献
WO2006/39974 A1, ;
Page/Page column 7-8 ;
反应条件
1: 79 percent / 1) room temp., overnight; 2) 110 deg C, 1 h. 2: 60 percent / KOH / ethanol / 3 h / 120 °C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 45, # 11 p. 3182 - 3189
参考文献
SPOFA, spojene podniky pro zdravotnickou vyrobu
Patent: US4243805 A1, 1981 ;
