2-氟-5-硝基苯甲酰氯合成路线 （共 10 条）
反应条件
1: methylmagnesium bromide With zinc dibromide in tetrahydrofuran; diethyl ether T=-78 - 20°C; 2: 2-fluoro-5-nitro-benzoyl chloride With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether T=-78 - 20°C; Further stages.;
参考文献
Fang, Yuan-Qing; Lautens, Mark
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 538 - 549
反应条件
thionyl chloride in benzene
12 h; Inert atmosphereReflux;
参考文献
Bunce, Richard A.; Schammerhorn, James E.; Sigle, Jessica
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 2 p. 373 - 380
反应条件
in tetrahydrofuran; N-methyl-acetamide; dichloromethane
参考文献
CELL THERAPEUTICS, INC.
Patent: US2002/107269 A1, 2002 ;
参考文献
Reich, Siegfried Heinz; Bleckman, Ted Michael; Kephart, Susan Elizabeth; Romines, William Henry; Wallace, Michael B.
Patent: US2002/161022 A1, 2002 ;
参考文献
Roussel Uclaf
Patent: US4801717 A1, 1989 ;
反应条件
1: 85 percent / KNO3; conc. H2SO4 / 20 °C
2: oxalyl chloride; DMF / CH2Cl2 / 20 °C
View Scheme
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
参考文献
Scherer,O.; Hahn,H.
Justus Liebigs Annalen der Chemie, 1964 , vol. 677, p. 83 - 95
反应条件
1: HNO3, H2SO4
2: aq. FeCl3
View Scheme
参考文献
Scherer,O.; Hahn,H.
Justus Liebigs Annalen der Chemie, 1964 , vol. 677, p. 83 - 95
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C;
参考文献
Deetz, Martin J.; Malerich, Jeremiah P.; Beatty, Alicia M.; Smith, Bradley D.
Tetrahedron Letters, 2001 , vol. 42, # 10 p. 1851 - 1854
反应条件
1: sodium azide / CH2Cl2; dimethylformamide / 20 °C
2: CH2Cl2; dimethylformamide / Heating
3: 85 percent / H2 / palladium black / methanol / 20 °C
View Scheme
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
