5-(溴甲基)-2-氟苯甲酸甲酯合成路线 （共 6 条）
反应条件
water in methanol Alkaline conditions;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
6.5 h; Inert atmosphereReflux;
参考文献
ETERNITY BIOSCIENCE INC.; LIU, Dong; ZHANG, Minsheng; HE, Kan; ZHANG, Lianshan
Patent: WO2012/125521 A1, 2012 ;
Location in patent: Page/Page column 35; 36 ;
WO 2012/125521 A1
反应条件
1: 94 percent / K2CO3 / acetone / Heating
2: NBS; AIBN / CCl4 / 20 h / Heating
View Scheme
参考文献
Gauuan, Polivina Jolicia F; Trova, Michael P; Gregor-Boros, Livia; Bocckino, Stephen B; Crapo, James D; Day, Brian J
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 9 p. 3013 - 3021
反应条件
1: 75 percent aq. H2SO4 / 0.5 h / 150 °C
2: aq. HCl / 14 h / Heating
3: 15 percent / NBS; (PhCO)2O2 / CCl4
View Scheme
参考文献
Patel, Mona; Rodgers, James D.; McHugh Jr., Robert J.; Johnson, Barry L.; Cordova, Beverly C.; Klabe, Ronald M.; Bacheler, Lee T.; Erickson-Viitanen, Susan; Soo S, Ko
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 22 p. 3217 - 3220
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
20 h; Heating;
参考文献
Gauuan, Polivina Jolicia F; Trova, Michael P; Gregor-Boros, Livia; Bocckino, Stephen B; Crapo, James D; Day, Brian J
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 9 p. 3013 - 3021
反应条件
water in methanol
Alkaline conditions;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
