6-甲基-2,4-蝶啶二胺合成路线 （共 26 条）
反应条件
1: 1.) bromine, benzoyl peroxide / 1.) acetic acid, reflux, 6 h, 2.) DMF, 70 deg C, 4 h 2: trifluoroacetic acid / 0.33 h / Ambient temperature View Scheme
参考文献
Cheung, H.T. Andrew; Smal, Mary; Chau, Diem Dieu
Heterocycles, 1987 , vol. 25, p. 507 - 514
反应条件
sodium hydroxide; sodium hydrogensulfite in water
参考文献
Lonza Ltd.
Patent: US4224446 A1, 1980 ;
反应条件
ammonium hydroxide in 1,4-dioxane
96 h; Ambient temperature;
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
perchloric acid
T=70 - 80°C; 0.25 h;
参考文献
Goswami, Shyamaprosad; Maity, Annada C.; Fun, Hoong-Kun
European Journal of Organic Chemistry, 2007 , # 24 p. 4056 - 4064
反应条件
in methanol
2 h; Heating;
参考文献
Taghavi-Moghadam, Shahriyar; Pfleiderer, Wolfgang
Tetrahedron Letters, 1997 , vol. 38, # 39 p. 6835 - 6836
反应条件
triethylamine
T=20°C; 240 h;
参考文献
Zav'yalov, S. I.; Zavozin, A. G.; Ezhova, G. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 11 p. 2183 - 2185
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 11 p. 2626 - 2628
反应条件
piperidine in water
T=20°C; 168 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Zav'yalov, S. I.; Zavozin, A. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 7 p. 1355 - 1357
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 7 p. 1666 - 1668
反应条件
1: 40 percent / 4-dimethylaminopyridine / 3 h / Heating
2: 44 percent / 4-chlorophenyl phosphorodichloridate, pyridine / 48 h / Ambient temperature
3: 96 percent / aq. NH3 / dioxane / 0.5 h / Ambient temperature
4: 89 percent / aq. NH3 / dioxane / 96 h / Ambient temperature
View Scheme
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
1: 44 percent / 4-chlorophenyl phosphorodichloridate, pyridine / 48 h / Ambient temperature
2: 96 percent / aq. NH3 / dioxane / 0.5 h / Ambient temperature
3: 89 percent / aq. NH3 / dioxane / 96 h / Ambient temperature
View Scheme
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
1: 96 percent / aq. NH3 / dioxane / 0.5 h / Ambient temperature
2: 89 percent / aq. NH3 / dioxane / 96 h / Ambient temperature
View Scheme
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
