N-(3-氯-4-甲氧基苯基)乙酰胺合成路线 （共 14 条）
反应条件
in dichloromethane T=25 - 30°C; 3 h;
参考文献
Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.
Patent: US2003/236287 A1, 2003 ;
Location in patent: Page 43, 44 ;
US 20030236287 A1
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in 1,4-dioxane; diethyl ether 5 h; Ambient temperature;
参考文献
Kuehm-Caubere, Catherine; Caubere, Paul; Jamart-Gregoire, Brigitte; Pfeiffer, Bruno; Guardiola-Lemaitre, Beatrice; Manechez, Dominique; Renard, Pierre
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 1 p. 51 - 61
参考文献
WO2012/45196 A1, ;
Page/Page column 52 ;
WO 2012/045196 A1
反应条件
1: 89 percent / iron, acetic acid / H2O / 3 h / Heating 2: 80 percent / acetic acid / 0.25 h / 100 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 19 p. 2751 - 2758
反应条件
hydrogenchloride; 3-chloro-benzenecarboperoxoic acid T=20°C; 0.5 h; Title compound not separated from byproducts;
参考文献
Synthetic Communications, , vol. 21, # 18-19 p. 1917 - 1922
反应条件
CF3CO3H; titanium tetrachloride in dichloromethane
参考文献
Canadian Journal of Chemistry, , vol. 50, p. 1233 - 1240
反应条件
1: fuming nitric acid 2: tin dichloride; hydrochloric acid 3: durch Acetylierung View Scheme
参考文献
Chemische Berichte, , vol. 32, p. 2623
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, , p. 1625
参考文献
Chemische Berichte, , vol. 32, p. 2623
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, , p. 1625
反应条件
aluminium trichloride; phenylmethanethiol in dichloromethane 1) 0 deg C, 2) r.t., 3 h; Yield given;
参考文献
Kuehm-Caubere, Catherine; Caubere, Paul; Jamart-Gregoire, Brigitte; Pfeiffer, Bruno; Guardiola-Lemaitre, Beatrice; Manechez, Dominique; Renard, Pierre
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 1 p. 51 - 61
反应条件
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 2: conc. sulfuric acid / 0.25 h / 100 °C View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; XU, Xiangdong; DINGES, Jurgent; HASVOLD, Lisa; LONGENECKER, Kenton, L.
Patent: WO2012/45196 A1, 2012 ;
WO 2012/045196 A1
