9-(2-羟乙基)腺嘌呤合成路线 （共 23 条）
反应条件
sodium hydroxide in N,N-dimethyl-formamide 24 h; Reflux;
参考文献
Bouhadir, Kamal H.; Abramian, Lara; Ezzeddine, Alaa; Usher, Karyn; Vladimirov, Nikolay
Molecules, 2012 , vol. 17, # 11 p. 13290 - 13306
反应条件
sodium hydroxide in DMF (N,N-dimethyl-formamide) T=150 - 160°C; 3 h; Heating / reflux;
参考文献
WO2004/14912 A1, ;
Page 10-13 ;
反应条件
ammonia in ethanol T=120°C; 15 h;
参考文献
Howson, William; Taylor, Edwin Michael; Parsons, Michael Edward; Novelli, Riccardo; Wilczynska, Maria Aleksandra; Harris, Deborah Tracy
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 433 - 440
反应条件
sodium hydroxide in N,N-dimethyl-formamide; toluene
参考文献
Becker, Mark W.; Chapman, Harlan H.; Cihlar, Tomas; Eisenberg, Eugene J.; He, Gong-Xi; Kernan, Michael R.; Lee, William A.; Prisbe, Ernest J.; Rohloff, John C.; Sparacino, Mark L.
Patent: US2004/18150 A1, 2004 ;
反应条件
lithium hydroxide in tetrahydrofuran; water Ambient temperature;
参考文献
Zhou, Jingian; Bouhadir, Kamal; Webb, Thomas R.; Shevlin, Philip B.
Tetrahedron Letters, 1997 , vol. 38, # 23 p. 4037 - 4038
反应条件
silver(l) oxide in water 1.5 h; Heating;
参考文献
Holy, Antonin; Kohoutova, Jitka; Merta, Ales; Votruba, Ivan
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 2 p. 459 - 477
反应条件
potassium carbonate in N,N-dimethyl-formamide T=25°C; 144 h; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 7 p. 2812 - 2822
反应条件
1.1: NaH / dimethylformamide / 1 h / 60 °C 1.2: dimethylformamide / 16 h / 60 °C 2.1: 5.87 g / NH3 / methanol / 14 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7799 - 7806
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
European Journal of Medicinal Chemistry, , vol. 70, p. 525 - 535
反应条件
1: acetic anhydride / 3 h / Heating 2: 17 percent / NH3 / ethanol / 15 h / 120 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 23, p. 433 - 440
