5-苯基-3-异唑甲酸乙酯合成路线 （共 33 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane in chloroform T=60°C; 40 h;
参考文献
Cecchi, Luca; De Sarlo, Francesco; Machetti, Fabrizio
European Journal of Organic Chemistry, 2006 , # 21 p. 4852 - 4860
反应条件
triethylamine in diethyl ether T=20°C; 3 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DHAR, T.G. Murali; XIAO, Hai-Yun; WATTERSON, Scott Hunter; KO, Soo S.; DYCKMAN, Alaric J.; LANGEVINE, Charles M.; DAS, Jagabandhu; CHERNEY, Robert J.
Patent: WO2011/59784 A1, 2011 ;
Location in patent: Page/Page column 83-84 ;
WO 2011/059784 A1
反应条件
hydroxylamine hydrochloride in tetrahydrofuran; ethanol T=20°C; 14 h; Heating / refluxMolecular sieve;
参考文献
Chapal, Nicolas; McNicol, Patricia; Jette, Lucie
Patent: US2006/223884 A1, 2006 ;
Location in patent: Page/Page column 57 ;
反应条件
hydroxylamine hydrochloride in ethanol 2 h; Heating;
参考文献
Pei; Wickhan
Tetrahedron Letters, 1993 , vol. 34, # 47 p. 7509 - 7512
反应条件
1: With TsNHOH; potassium carbonate in ethanol T=0°C; 2: With triethylamine; p-toluenesulfonyl chloride in acetonitrile T=20°C; 4 h; regioselective reaction;
参考文献
Tang, Shibing; He, Jinmei; Sun, Yongquan; He, Liuer; She, Xuegong
Organic Letters, 2009 , vol. 11, # 17 p. 3982 - 3985
反应条件
triethylamine in tetrahydrofuran T=20°C; 16 h;
参考文献
Kozikowski, Alan P.; Tapadar, Subhasish; Luchini, Doris N.; Ki, Hwan Kim; Billadeau, Daniel D.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4370 - 4373
反应条件
1: With sodium ethanolate in ethanol T=20°C; 20 h; 2: With hydroxylamine hydrochloride; acetic acid in ethanol; water 20 h; 3: With toluene-4-sulfonic acid in ethanol 2 h; Reflux;
参考文献
Musatov; Starodubtseva; Rakishev; Turova; Vinogradov
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 8 p. 1199 - 1203
反应条件
trifluoroacetic acid; sodium nitrite T=20°C;
参考文献
Kadzhaeva; Trofimova; Fedotov; Potekhin; Gazzaeva; Mochalov; Zefirov
Chemistry of Heterocyclic Compounds, 2009 , vol. 45, # 5 p. 595 - 605
反应条件
hydroxylamine hydrochloride in ethanol 2 h; Reflux;
参考文献
Letters in Organic Chemistry, , vol. 7, # 1 p. 32 - 38
反应条件
1.1: NaH / toluene / 45 - 50 °C 1.2: toluene / 1.5 h / Heating 2.1: NH2OH*HCl / ethanol / 1 h / Heating View Scheme
参考文献
Synthesis, , # 15 p. 2325 - 2330
