反,反,顺-1,5,9-环十二烷基三烯合成路线 （共 58 条）
反应条件
1: 75 percent / triethylamine / 16 h / 25 °C
2: 100 percent / diethyl ether / 2 h / 5 °C
3: 67 percent / Li2CO3 / dimethylformamide / 1 h / 80 °C
4: NaBH4, CeCl3 / methanol / 0.17 h / 20 °C
5: 43 percent / 80percent aq. formic acid / 0.67 h / 70 °C
6: 100 percent / H2 / Pd/C / ethyl acetate
View Scheme
参考文献
Mehta, Goverdhan; Rao, K. Srinivas
Tetrahedron Letters, 1984 , vol. 25, # 17 p. 1839 - 1842
反应条件
hydrogen; ruthenium trichloride; formaldehyd; 1,6-hexanedioic acid; ethanol; triphenylphosphine in water
T=100 - 140°C; P=15001.5 Torr; 24 h;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2005/30689 A2, 2005 ;
Location in patent: Page/Page column 27-28 ;
反应条件
hydrogen; (o-OC6H4CH3)3PRuCl(PPh3)2 in benzene
T=120°C; P=3361.5 Torr; 2 h; in the absence of air; Product distribution;
参考文献
Lewis,L.N.
Journal of the American Chemical Society, 1986 , vol. 108, p. 743
反应条件
hydrogen; (o-OC6H4CH3)3PRuCl(PPh3)2 in benzene
the reaction was carried out in two steps (beetwen them the reaction mixture was exposed to air); 1.) p=65 psi, 120 deg C, 2 h, 2.) p=70 psi, 95 deg C, 17 h; Product distribution;
参考文献
Lewis,L.N.
Journal of the American Chemical Society, 1986 , vol. 108, p. 743
反应条件
Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Haufe, Guenter
Zeitschrift fuer Chemie (Stuttgart, Germany), 1984 , vol. 24, # 8 p. 288 - 289
反应条件
2-cyanopyridinium chlorochromate; Celite in dichloromethane
Ambient temperature;
参考文献
Guerrero, Angel F.; Kim, Ho-jin; Schlecht, Matthew F.
Tetrahedron Letters, 1988 , vol. 29, # 51 p. 6707 - 6710
反应条件
N-bromosuccinmide; sulfuric acid
Further byproducts given;
参考文献
Haufe, Guenter; Muehlstaedt, Manfred
Tetrahedron Letters, 1984 , vol. 25, # 17 p. 1777 - 1780
反应条件
1: 75 percent / triethylamine / 16 h / 25 °C
2: 100 percent / diethyl ether / 2 h / 5 °C
3: 67 percent / Li2CO3 / dimethylformamide / 1 h / 80 °C
4: diethyl ether
5: 45 percent / 80percent aq. formic acid / 0.67 h / 85 °C
6: 100 percent / H2 / Pd/C / ethyl acetate
View Scheme
参考文献
Mehta, Goverdhan; Rao, K. Srinivas
Tetrahedron Letters, 1984 , vol. 25, # 17 p. 1839 - 1842
