4,6-二氯吡啶-3-酰胺合成路线 （共 5 条）
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 25°C; 3 h; 2: With ammonia in tetrahydrofuran; water T=0°C; 1 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/217417 A1, 2006 ;
Location in patent: Page/Page column 12; 13 ;
反应条件
1: With trichlorophosphate T=100°C; 4 h; 2: With ammonium hydroxide in water
参考文献
WO2010/129802 A1, ;
Page/Page column 207 ;
WO 2010/129802 A1
反应条件
1: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide 0.5 h; 2: With ammonia in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
US2012/108566 A1, ;
Page/Page column 55 ;
US 20120108566 A1
反应条件
1.1: water / 1,4-dioxane / 20 °C 1.2: pH 2 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h 2.2: 1 h / 20 °C View Scheme
参考文献
US2012/108566 A1, ;
US 20120108566 A1
反应条件
sodium hydroxide; water; bromine in 1,4-dioxane T=0 - 25°C; 18 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/217417 A1, 2006 ;
Location in patent: Page/Page column 13 ;
