1-苯基甲基-2,4-哌啶二酮合成路线 （共 9 条）
参考文献
Nikken Chemicals Co., Ltd.
Patent: US6235736 B1, 2001 ;
反应条件
potassium carbonate in dimethyl sulfoxide 24 h;
参考文献
ELI LILLY AND COMPANY
Patent: EP1204660 B1, 2004 ;
Location in patent: Page 14 - 15 ;
反应条件
oxalic acid in water
15 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: EP1204660 B1, 2004 ;
Location in patent: Page 14 ;
反应条件
hydrogenchloride; water in tetrahydrofuran
T=20°C; 3 h;
参考文献
Almirall, S.A.
Patent: EP2526945 A1, 2012 ;
Location in patent: Page/Page column 49-50 ;
EP 2526945 A1
反应条件
chromium(VI) oxide; sulfuric acid in water; acetone
T=20°C; 0.0833333 h;
参考文献
Chang, Dongliang; Feiten, Hans-Juergen; Witholt, Bernard; Li, Zhi
Tetrahedron Asymmetry, 2002 , vol. 13, # 19 p. 2141 - 2147
反应条件
sodium hydroxide in water
T=20°C; 1 h;
参考文献
Zerovnik, Darja; Groselj, Uros; Kralj, David; Malavasic, Crt; Bezensek, Jure; Dahmann, Georg; Stare, Katarina; Meden, Anton; Stanovnik, Branko; Svete, Jurij
Synthesis, 2010 , # 19 art. no. T09210SS, p. 3363 - 3373
反应条件
1.1: toluene-4-sulfonic acid / methanol / 1.5 h / Reflux
1.2: 5 h / Reflux
1.3: 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h
2.2: 3.5 h / 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Almirall, S.A.
Patent: EP2526945 A1, 2012 ;
EP 2526945 A1
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
2: sodium hydride; ethanol / 0 - 20 °C
3: water / acetonitrile / 3.5 h / |Reflux
View Scheme
参考文献
Ishida, Takayuki; Takemoto, Yoshiji
Tetrahedron, 2013 , vol. 69, # 23 p. 4517 - 4523
反应条件
1: sodium hydride; ethanol / 0 - 20 °C
2: water / acetonitrile / 3.5 h / |Reflux
View Scheme
参考文献
Ishida, Takayuki; Takemoto, Yoshiji
Tetrahedron, 2013 , vol. 69, # 23 p. 4517 - 4523
