4-异氰基-N,N-二甲基苯胺合成路线 （共 4 条）
反应条件
4-methyl-morpholine; trichloromethyl chloroformate in dichloromethane
T=-30°C; 1 h;
参考文献
Kamer, Paul C. J.; Nolte, Roeland J. M.; Drenth, Wiendelt
Journal of the American Chemical Society, 1988 , vol. 110, # 20 p. 6818 - 6825
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane; chloroform
12 h;
参考文献
Barton, Derek H. R.; Ozbalik, Nubar; Vacher, Bernard
Tetrahedron, 1988 , vol. 44, # 12 p. 3501 - 3512
反应条件
1: 76 percent / toluene
2: 79 percent / N-methylmorpholine, diphosgene / CH2Cl2 / 1 h / -30 °C
View Scheme
参考文献
Kamer, Paul C. J.; Nolte, Roeland J. M.; Drenth, Wiendelt
Journal of the American Chemical Society, 1988 , vol. 110, # 20 p. 6818 - 6825
反应条件
1: in ethanol
0.25 h; Heating;
2: in toluene
T=90°C; 30 h;
参考文献
Mironov; Babaev
Russian Journal of General Chemistry, 2010 , vol. 80, # 12 p. 2647 - 2654
