Alpha-(1-甲基乙基)苯乙醇合成路线 （共 32 条）
反应条件
naphthalene; lithium in tetrahydrofuran
T=-78 - 20°C; 5 h;
参考文献
Alonso, Emma; Guijarro, David; Yus, Miguel
Tetrahedron, 1995 , vol. 51, # 9 p. 2699 - 2708
反应条件
naphthalene; lithium in tetrahydrofuran
T=-30°C; Barbier-type reaction; 3 h;
参考文献
Guijarro, David; Yus, Miguel
Journal of Organometallic Chemistry, 2001 , vol. 624, # 1-2 p. 53 - 57
参考文献
Levy
Bulletin de la Societe Chimique de France, 1923 , vol. <4> 33, p. 1662
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Verbel, Joel; Carrie, Robert
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 3-4 p. 116 - 124
反应条件
methanol; sodium tetrahydroborate
参考文献
Rioz-Martinez, Ana; De Gonzalo; Torres Pazmino, Daniel E.; Fraaije, Marco-W.; Gotor, Vicente
Journal of Organic Chemistry, 2010 , vol. 75, # 6 p. 2073 - 2076
反应条件
1: NaH / diethyl ether; ethanol / 2 h / Heating
2: pyridine
3: 28 percent / LDA / tetrahydrofuran / 1.) 30 min, -78 deg C, 2.) 30 min, 0 deg C
4: pyridine
5: 82 percent / SO2Cl2 / CH2Cl2 / 2 h / Heating
6: H2 / 10percent Pd/C / methanol / 20 h / Ambient temperature
View Scheme
参考文献
Ohtsuka, Yasuo; Oishi, Takeshi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 443 - 453
反应条件
1: pyridine
2: 82 percent / SO2Cl2 / CH2Cl2 / 2 h / Heating
3: H2 / 10percent Pd/C / methanol / 20 h / Ambient temperature
View Scheme
参考文献
Ohtsuka, Yasuo; Oishi, Takeshi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 443 - 453
反应条件
1: 28 percent / LDA / tetrahydrofuran / 1.) 30 min, -78 deg C, 2.) 30 min, 0 deg C
2: pyridine
3: 82 percent / SO2Cl2 / CH2Cl2 / 2 h / Heating
4: H2 / 10percent Pd/C / methanol / 20 h / Ambient temperature
View Scheme
参考文献
Ohtsuka, Yasuo; Oishi, Takeshi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 443 - 453
反应条件
1: pyridine
2: 28 percent / LDA / tetrahydrofuran / 1.) 30 min, -78 deg C, 2.) 30 min, 0 deg C
3: pyridine
4: 82 percent / SO2Cl2 / CH2Cl2 / 2 h / Heating
5: H2 / 10percent Pd/C / methanol / 20 h / Ambient temperature
View Scheme
参考文献
Ohtsuka, Yasuo; Oishi, Takeshi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 443 - 453
反应条件
hydrogen; palladium on activated charcoal in methanol
20 h; Ambient temperature;
参考文献
Ohtsuka, Yasuo; Oishi, Takeshi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 443 - 453
反应条件
1: 82 percent / SO2Cl2 / CH2Cl2 / 2 h / Heating
2: H2 / 10percent Pd/C / methanol / 20 h / Ambient temperature
View Scheme
参考文献
Ohtsuka, Yasuo; Oishi, Takeshi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 443 - 453
