3-乙炔基-α,α,α-三氟甲苯合成路线 （共 22 条）
反应条件
potassium carbonate in ethanol T=20°C; 16 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/94822 A1, 2005 ;
Location in patent: Page/Page column 31 ;
WO 2005/094822 A1
反应条件
n-butyllithium in diethyl ether
参考文献
Kodaira, Kazuo; Okuhara, Kunio
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 5 p. 1625 - 1632
反应条件
potassium hydroxide in diethyl ether; water T=180 - 220°C;
参考文献
Mesnard, Danielle; Bernadou, Francoise; Miginiac, Leone
Journal of Chemical Research, Miniprint, 1981 , # 9 p. 3216 - 3245
反应条件
1: 1.) n-BuLi / 1.) ether, hexane, -40 deg C to 0 deg C, 1 h, 2.) ether, hexane, -40 deg C to RT, 1 h 2: pentane / 23 °C / Irradiation View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 73, # 2 p. 191 - 203
反应条件
1: Br2 / diethyl ether / 2 h / -10 °C 2: 52 percent / KOH / H2O; diethyl ether / 180 - 220 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 9 p. 3216 - 3245
参考文献
Journal of the American Chemical Society, , vol. 85, p. 3492 - 3496
反应条件
1: KHSO4 2: (i) Br2, (ii) KOH 3: KOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 85, p. 3492 - 3496
反应条件
2: KHSO4 3: (i) Br2, (ii) KOH 4: KOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 85, p. 3492 - 3496
反应条件
sodium hydroxide T=160°C; retro-Favorskii cleveage;
参考文献
Heterocycles, , vol. 71, # 9 p. 1967 - 1974
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 20 °C / Inert atmosphere 2: methanol; potassium carbonate / dichloromethane / 2 h / 20 °C / Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 18, # 32 p. 9798 - 9801
