2-羟基-5-甲氧基苯乙酮合成路线 （共 63 条）
反应条件
1: K2CO3; acetone
2: sodium ethylate; ethanol
View Scheme
参考文献
Whalley
Journal of the Chemical Society, 1953 , p. 3479,3482
反应条件
1: sodium hydride / toluene / 4.5 h / 100 °C / |Cooling with ice
2: trichlorophosphate; triethylamine / 1.5 h / |Reflux
View Scheme
参考文献
Zhang, Wenjuan; Li, Zhi; Zhou, Meng; Wu, Feng; Hou, Xueyan; Luo, Hao; Liu, Hao; Han, Xuan; Yan, Guoyi; Ding, Zhenyu; Li, Rui
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 799 - 807
反应条件
sodium hydride; benzene
Erhitzen des Reaktionsprodukts mit Essigsaeure und wss. Salzsaeure;
参考文献
Wiley
Journal of the American Chemical Society, 1951 , vol. 73, p. 4205,4207
反应条件
1: p-toluenesulfonic acid
2: 42 percent / benzene / Irradiation
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参考文献
Jongebreur
Pharmaceutisch Weekblad, 1951 , vol. 86, p. 661,668
反应条件
pyrrolidine in methanol
8 h; Heating;
参考文献
Yamato; Hashigaki; Tsutsumi; Tasaka
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 12 p. 3494 - 3498
反应条件
1,4-dioxane; sodium
Erhitzen des Reaktionsprodukts mit Aethanol und konz. Salzsaeure;
参考文献
Wiley
Journal of the American Chemical Society, 1952 , vol. 74, p. 4326
反应条件
1: 50percent NaH/mineral oil / tetrahydrofuran / Ambient temperature
2: 50percent NaH/mineral oil, 18 crown 6 / dioxane / 3 h / 65 °C
3: Redex CF resin
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参考文献
Humbert; Dagnaux; Cohen; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 1 p. 67 - 78
反应条件
1: pyridine; trichlorophosphate / 2 h / 20 °C
2: pyridine; potassium hydroxide / 2 h / 20 °C
3: sulfuric acid; acetic acid / 1 h / 100 °C
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参考文献
Giridhar, Rajani; Tamboli, Riyaj S.; Prajapati, Dhaval G.; Soni, Sanket; Gupta, Sarita; Yadav
Medicinal Chemistry Research, 2013 , vol. 22, # 7 p. 3309 - 3315
反应条件
lithium diisopropyl amide
2) -40 deg C; Yield given. Multistep reaction;
参考文献
Banerji, A.; Goomer, N. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 9 p. 885 - 886
反应条件
1: potassium hydroxide / ethanol / 15 h / 50 °C
2: dihydrogen peroxide; sodium hydroxide / methanol / 15 h / 20 °C
View Scheme
参考文献
Ravichandran; Singh; Donnelly; Migliore; Johnson; Fishwick; Luke; Martin; Maudsley; Fugmann; Moaddel
Journal of Molecular Graphics and Modelling, 2014 , vol. 49, p. 38 - 46
