2-羟基-5-甲氧基苯乙酮合成路线 （共 63 条）
反应条件
copper(ll) bromide in methanol T=70°C; 0.5 h; Microwave irradiationInert atmosphere;
参考文献
Mutai, Toshiki; Sawatani, Hirotaka; Shida, Toshihide; Shono, Hideaki; Araki, Koji
Journal of Organic Chemistry, 2013 , vol. 78, # 6 p. 2482 - 2489
反应条件
1.1: sulfur; morpholine; p-toluenesulfonic acid / 8 h / 120 - 130 °C 1.2: 64 percent / sodium hydroxide; tetrabutylammonium bromide / H2O / 8 h / 100 °C 2.1: 85 percent / phosphorus oxychloride / 1,2-dichloro-ethane / 16 h / 20 °C View Scheme
参考文献
Venkateswarlu, Somepalli; Panchagnula, Gopala K.; Guraiah, Mothukuri Bala; Subbaraju, Gottumukkala V.
Tetrahedron, 2006 , vol. 62, # 42 p. 9855 - 9860
反应条件
1: ammonia / methanol / 2 h / 20 °C / Inert atmosphere 2: sodium hypochlorite / water; isopropyl alcohol / 0 - 10 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 23 p. 6300 - 6303
反应条件
pyridine T=50°C; 0.5 h;
参考文献
Journal of the Chinese Chemical Society, , vol. 51, # 6 p. 1389 - 1394
反应条件
pyridine T=80°C; 3 h;
参考文献
Castaneda, Isabel C. Henao; Ulic, Sonia E.; Vedova, Carlos O. Della; Metzler-Nolte, Nils; Jios, Jorge L.
Tetrahedron Letters, 2011 , vol. 52, # 13 p. 1436 - 1440
反应条件
1: 73 percent / LiH / tetrahydrofuran / 3 h / Heating 2: 91 percent / AcOH; HCl / 0.05 h / Heating View Scheme
参考文献
Sosnovskikh; Usachev
Russian Chemical Bulletin, 2001 , vol. 50, # 3 p. 453 - 455
反应条件
1: 1.) lithium bis(trimethylsilyl)amide / 1.) a.) THF, -78 deg C, b.) -10 deg C, 2 h, 2.) a.) from -78 deg C to 25 deg C, 3-4 h, b.) RT, 4 h 2: 1.) Mg, CCl4 / 1.) ethanol, 50 to 55 deg C, 5 to 6 h, 2.) benzene, reflux, 8 h View Scheme
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Burg, Debra L.; Geahlen, Robert L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 798 - 806
反应条件
lithium hexamethyldisilazane 1.) a.) THF, -78 deg C, b.) -10 deg C, 2 h, 2.) a.) from -78 deg C to 25 deg C, 3-4 h, b.) RT, 4 h; Yield given. Multistep reaction;
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Burg, Debra L.; Geahlen, Robert L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 798 - 806
反应条件
1: 1.) lithium bis(trimethylsilyl)amide / 1.) a.) THF, -78 deg C, b.) -10 deg C, 2 h, 2.) a.) from -78 deg C to 25 deg C, 3-4 h, b.) RT, 4 h 2: 1.) Mg, CCl4 / 1.) ethanol, 50 to 55 deg C, 5 to 6 h, 2.) benzene, reflux, 8 h 3: 58 percent / pyridine hydrochloride / quinoline / 6 h / 180 - 185 °C 4: 91 percent / H2 / 5percent Pd/C / dioxane / 8 h / 2068.6 Torr View Scheme
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Burg, Debra L.; Geahlen, Robert L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 798 - 806
反应条件
iodine; aniline in methanol T=40°C; Mannich type reaction; 7 h;
参考文献
Kavala, Veerababurao; Lin, Chunchi; Kuo, Chun-Wei; Fang, Hulin; Yao, Ching-Fa
Tetrahedron, 2012 , vol. 68, # 4 p. 1321 - 1329
