2-羟基-5-甲氧基苯乙酮合成路线 （共 63 条）
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 288, p. 102,107,108
参考文献
Journal of the Indian Chemical Society, , vol. 27, p. 531,532
参考文献
Gazzetta Chimica Italiana, , vol. 78, p. 16,19
Journal of the Chemical Society, , p. 1922,1926
反应条件
1.1: sulfur; morpholine; p-toluenesulfonic acid / 8 h / 120 - 130 °C 1.2: 64 percent / sodium hydroxide; tetrabutylammonium bromide / H2O / 8 h / 100 °C 2.1: 85 percent / phosphorus oxychloride / 1,2-dichloro-ethane / 16 h / 20 °C 3.1: 66 percent / pyridine hydrochloride / 3 h / 180 - 190 °C 4.1: potassium hydroxide / ethanol / 15 h / 20 °C / pH 8 View Scheme
参考文献
Venkateswarlu, Somepalli; Panchagnula, Gopala K.; Guraiah, Mothukuri Bala; Subbaraju, Gottumukkala V.
Tetrahedron, 2006 , vol. 62, # 42 p. 9855 - 9860
反应条件
pyridinium p-toluenesulfonate 0.025 h; microwave irradiation;
参考文献
Lamba, Mandeep S.; Makrandi, Jagdish K.
Journal of Chemical Research, 2007 , # 10 p. 585 - 586
反应条件
1: 1.) lithium bis(trimethylsilyl)amide / 1.) a.) THF, -78 deg C, b.) -10 deg C, 2 h, 2.) a.) from -78 deg C to 25 deg C, 3-4 h, b.) RT, 4 h 2: 1.) Mg, CCl4 / 1.) ethanol, 50 to 55 deg C, 5 to 6 h, 2.) benzene, reflux, 8 h 3: 58 percent / pyridine hydrochloride / quinoline / 6 h / 180 - 185 °C View Scheme
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Burg, Debra L.; Geahlen, Robert L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 798 - 806
反应条件
1: pyridine; hydroxylamine hydrochloride / ethanol / 20 °C 2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / |Inert atmosphere View Scheme
参考文献
Newsome, Jeffery J.; Hassani, Mary; Swann, Elizabeth; Bibby, Jane M.; Beall, Howard D.; Moody, Christopher J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 2999 - 3009
反应条件
1: in tetrahydrofuran T=0 - 20°C; 16.5 h; 2: With ammonium chloride in tetrahydrofuran; water
参考文献
Roche Palo Alto LLC
Patent: US2007/49609 A1, 2007 ;
Location in patent: Page/Page column 92 ;
US 20070049609 A1
反应条件
in tetrahydrofuran T=5 - 20°C;
参考文献
Jahangir, Alam; Alam, Muzaffar; Carter, David S.; Dillon, Michael P.; Bois, Daisy Joe Du; Ford, Anthony P.D.W.; Gever, Joel R.; Lin, Clara; Wagner, Paul J.; Zhai, Yansheng; Zira, Jeff
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1632 - 1635
参考文献
Degen, Shane J.; Mueller, Kristen L.; Shen, Hong C.; Mulder, Jason A.; Golding, Geoffrey M.; Wei, Lin-li; Zificsak, Craig A.; Neeno-Eckwall, Amy; Hsung, Richard P.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 973 - 978
