2-二氟甲基-1H-苯并咪唑合成路线 （共 9 条）
参考文献
Rene, Olivier; Souverneva, Alexandra; Magnuson, Steven R.; Fauber, Benjamin P.
Tetrahedron Letters, 2013 , vol. 54, # 3 p. 201 - 204
反应条件
T=98 - 100°C; 3 h; ConcentrationTemperatureTime;
参考文献
RHODIA OPERATIONS; RHODIA (CHINA) CO., LTD.; ZHANG, Tao; MERCIER, Claude; BUISINE, Olivier
Patent: WO2013/123634 A1, 2013 ;
Location in patent: Paragraph 0025-0026 ;
反应条件
T=120°C; 3 h; Inert atmosphere;
参考文献
RHODIA OPERATIONS; RHODIA (CHINA) CO., LTD.; ZHANG, Tao; MERCIER, Claude; BUISINE, Olivier
Patent: WO2013/123634 A1, 2013 ;
Location in patent: Paragraph 0030 ;
反应条件
T=98 - 100°C; 3 h; Inert atmosphere;
参考文献
RHODIA OPERATIONS; RHODIA (CHINA) CO., LTD.; ZHANG, Tao; MERCIER, Claude; BUISINE, Olivier
Patent: WO2013/123634 A1, 2013 ;
Location in patent: Paragraph 0028 ;
反应条件
T=98 - 100°C; 3 h; Inert atmosphere;
参考文献
RHODIA OPERATIONS; RHODIA (CHINA) CO., LTD.; ZHANG, Tao; MERCIER, Claude; BUISINE, Olivier
Patent: WO2013/123634 A1, 2013 ;
Location in patent: Paragraph 0029 ;
反应条件
in diethyl ether T=15°C; 4 h;
参考文献
Pashkevich, K. I.; Skryabina, Z. E.; Saloutin, V. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 11 p. 2347 - 2353
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 11 p. 2527 - 2535
反应条件
in acetonitrile Cyclization;
参考文献
Chemical Research in Toxicology, , vol. 9, # 7 p. 1092 - 1102
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
US2007/244110 A1, ;
Page/Page column 4 ;
反应条件
1: 4,6-dichloro-N-morpholinyl-1,3,5-triazine-2-amine; 2-(difluoromethyl)-1H-benzo[d]imidazole With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 16 h; 2: 2,4,6-trichloro-pyrimidine in DMF (N,N-dimethyl-formamide) T=20°C; 1.5 h;
参考文献
EP1389617 A1, ;
Page 12 ;
