5-溴-4H-[1,2,4]噻唑-3-羧酸甲酯合成路线 （共 3 条）
反应条件
1: With sulfuric acid; sodium nitrite in water T=-3°C; 0.5 h; 2: With potassium bromide; copper(I) bromide in water T=25°C; 3 h;
参考文献
Zhu, Ruizhi; Qu, Fanqi; Quelever, Gilles; Peng, Ling
Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2389 - 2393
反应条件
thionyl chloride T=10 - 20°C;
参考文献
Konstantinova; Chudinov; Fateev; Matveev; Zhurilo; Shvets; Miroshnikov
Russian Journal of Bioorganic Chemistry, 2013 , vol. 39, # 1 p. 53 - 71
Bioorganicheskaya Khimiya, 2013 , vol. 39, # 1 p. 61 - 80,20
反应条件
ammonia in methanol T=125°C; 0.666667 h; Microwave irradiation;
参考文献
MERCK SHARP andamp; DOHME CORP.; SCYNEXIS, INC.; GREENLEE, Mark, L.; WILKENING, Robert; APGAR, James; SPERBECK, Donald; WILDONGER, Kenneth, James; MENG, Dongfang; PARKER, Dann, L.; PACOFSKY, Gregory, James; HEASLEY, Brian, Haid; MAMAI, Ahmed; NELSON, Kingsley
Patent: WO2010/19204 A1, 2010 ;
Location in patent: Page/Page column 70 ;
