7-氯-1-乙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸乙酯合成路线 （共 19 条）
反应条件
1: 90 percent / 2N NaOH / 2 h / Heating 2: 66 percent / 5 h / 130 - 140 °C 3: 85 percent / 87percent HCOOH / Heating View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 90 percent / 2N NaOH / 2 h / Heating 2: 66 percent / 5 h / 130 - 140 °C View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 90 percent / 2N NaOH / 2 h / Heating 2: 32 percent / 5 h / 130 - 140 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 12 p. 1358 - 1363
反应条件
1: With water; sodium hydroxide in ethanol T=90°C; 1.5 h; 2: With hydrogenchloride in ethanol; water pH=2;
参考文献
Niedermeier, Sabine; Singethan, Katrin; Rohrer, Sebastian G.; Matz, Magnus; Kossner, Markus; Diederich, Sandra; Maisner, Andrea; Schmitz, Jens; Hiltensperger, Georg; Baumann, Knut; Holzgrabe, Ulrike; Schneider-Schaulies, Jurgen
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4257 - 4265
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80 - 90°C; 10 h;
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
potassium carbonate; triethylamine in dichloromethane
T=40°C; 10 h;
参考文献
Kazimierczak, Jerzy; Kroszczynski, Wojciech; Gorecki, Bartlomiej; Smolinska, Jadwiga
Acta Poloniae Pharmaceutica, 1993 , vol. 50, # 4-5 p. 365 - 368
反应条件
1: 115 - 120 °C / 30-60 min
2: Dowtherm A / 1 h / 250 °C
3: potassium carbonate / 1.5 h / 190 °C
View Scheme
参考文献
Podanyi, Benjamin; Kereszturi, Geza; Vasvari-Debreczy, Lelle; Chinoin, Istvan Hermecz; Toth, Gabor
Magnetic Resonance in Chemistry, 1996 , vol. 34, # 11 p. 972 - 978
反应条件
1: Dowtherm A / 1 h / 250 °C
2: potassium carbonate / 1.5 h / 190 °C
View Scheme
参考文献
Podanyi, Benjamin; Kereszturi, Geza; Vasvari-Debreczy, Lelle; Chinoin, Istvan Hermecz; Toth, Gabor
Magnetic Resonance in Chemistry, 1996 , vol. 34, # 11 p. 972 - 978
反应条件
potassium tert-butylate in 1,4-dioxane
1.) 30 min, room temperature, 2.) 2 h, reflux;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: diethyl (4-fluoro-3-chloroanilino)methylenemalonate in diphenylether
Gould-Jacobs reaction; Reflux;
2: With sodium hydroxide in dimethyl sulfoxide
T=20°C; 0.5 h;
3: ethyl iodide in dimethyl sulfoxide
T=20°C; 72 h;
参考文献
Niedermeier, Sabine; Singethan, Katrin; Rohrer, Sebastian G.; Matz, Magnus; Kossner, Markus; Diederich, Sandra; Maisner, Andrea; Schmitz, Jens; Hiltensperger, Georg; Baumann, Knut; Holzgrabe, Ulrike; Schneider-Schaulies, Jurgen
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4257 - 4265
