7-氯-6-氟-4-4羟基-3-喹啉甲酸乙酯合成路线 （共 14 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80 - 90°C; 10 h;
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
potassium carbonate; triethylamine in dichloromethane
T=40°C; 10 h;
参考文献
Kazimierczak, Jerzy; Kroszczynski, Wojciech; Gorecki, Bartlomiej; Smolinska, Jadwiga
Acta Poloniae Pharmaceutica, 1993 , vol. 50, # 4-5 p. 365 - 368
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
2: 90 percent / 2N NaOH / 2 h / Heating
3: 66 percent / 5 h / 130 - 140 °C
4: 89 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
2: 90 percent / 2N NaOH / 2 h / Heating
3: 66 percent / 5 h / 130 - 140 °C
4: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
