7-氯-6-氟-4-4羟基-3-喹啉甲酸乙酯合成路线 （共 14 条）
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 2: 90 percent / 2N NaOH / 2 h / Heating 3: 66 percent / 5 h / 130 - 140 °C 4: 85 percent / 87percent HCOOH / Heating View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 2: 90 percent / 2N NaOH / 2 h / Heating 3: 66 percent / 5 h / 130 - 140 °C View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 2: 90 percent / 2N NaOH / 2 h / Heating 3: 32 percent / 5 h / 130 - 140 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 12 p. 1358 - 1363
反应条件
1: K2CO3 2: aq. NaOH View Scheme
参考文献
Vymed Corporation; SHETTY, B. Vithal
Patent: US2014/73631 A1, 2014 ;
参考文献
CENTRO MARGA PARA LA INVESTIGACION S.A.
Patent: EP376870 A1, 1990 ;
反应条件
1: |Reflux
2: 250 °C / |Reflux
View Scheme
参考文献
Saxena, Anil K.; Roy, Kuldeep K.; Singh, Supriya; Vishnoi; Kumar, Anil; Kashyap, Vivek Kr.; Kremer, Laurent; Srivastava, Ranjana; Srivastava, Brahm S.
International Journal of Antimicrobial Agents, 2013 , vol. 42, # 1 p. 27 - 35
参考文献
American Cyanamid Company
Patent: US4940710 A1, 1990 ;
参考文献
Laboratorie Roger Bellon; Dainippon Pharmaceutical
Patent: US4292317 A1, 1981 ;
US 4292317 A
反应条件
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
