2,3-二氢-1,5-苯并氧氮杂卓-4(5H)-酮合成路线 （共 9 条）
反应条件
1: 91 percent / Lawesson-reagent / tetrahydrofuran / 3 h / 20 °C 2: 5 h / 90 °C View Scheme
参考文献
Bartsch, Herbert; Erker, Thomas
Liebigs Annalen der Chemie, 1988 , p. 795 - 798
反应条件
phosphorus pentachloride 1.) toluene, 2 h, 90 deg C, 2.) toluene, 90 min, 90 deg C; Yield given. Multistep reaction;
参考文献
Bartsch, Herbert; Erker, Thomas
Liebigs Annalen der Chemie, 1988 , p. 795 - 798
反应条件
T=150 - 155°C; P=0.5 Torr;
参考文献
Huckle,D. et al.
Journal of the Chemical Society, 1965 , p. 1137 - 1141
反应条件
indium tribromide; silver trifluoromethanesulfonate in acetonitrile
T=90°C; Beckmann rearrangement; 2 h; Inert atmosphere; regioselective reaction;
参考文献
Tandon, Vishnu K.; Awasthi, Anoop K.; Maurya, Hardesh K.; Mishra, Pushyamitra
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 2 p. 424 - 427
反应条件
sodium azide; methanesulfonic acid
参考文献
Kamei, Katsuhide; Maeda, Noriko; Nomura, Kayoko; Shibata, Makoto; Katsuragi-Ogino, Ryoko; Koyama, Makoto; Nakajima, Mika; Inoue, Teruyoshi; Ohno, Tomochika; Tatsuoka, Toshio
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1978 - 1992
反应条件
1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 1 h / Reflux
2: indium tribromide; silver trifluoromethanesulfonate / acetonitrile / 2 h / 90 °C / Inert atmosphere
View Scheme
参考文献
Tandon, Vishnu K.; Awasthi, Anoop K.; Maurya, Hardesh K.; Mishra, Pushyamitra
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 2 p. 424 - 427
参考文献
Bhalerao,U.T.; Thyagarajan,G.
Indian Journal of Chemistry, 1969 , vol. 7, p. 429 - 433
反应条件
1: With borane-THF in tetrahydrofuran
T=70°C; 4 h;
2: With sodium hydroxide; water in ethyl acetate
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2008/124614 A1, 2008 ;
Location in patent: Page/Page column 45-46 ;
WO 2008/124614 A1
反应条件
sodium carbonate; diethyl chlorophosphate; triethylamine
1.) THF, 20 deg C, 30 min 2.) ethyl acetate, water; Yield given. Multistep reaction;
参考文献
Bartsch, Herbert; Erker, Thomas
Liebigs Annalen der Chemie, 1988 , p. 795 - 798
