2',4'-二氯-5'-氟苯乙酮合成路线 （共 19 条）
反应条件
aluminium trichloride
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 32, # 10 p. 3131 - 3134,3078 - 3081
反应条件
hydrogenchloride; acetic anhydride; aluminium trichloride
反应条件
AlCl3, aluminium chloride Friedel Crafts acylation;
参考文献
Hong, Jian; Zhang, Zonghua; Lei, Huoxing; Cheng, Haiying; Hu, Yufang; Yang, Wanliang; Liang, Yinglin; Das, Debasis; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2525 - 2528
反应条件
1: 1-butyl-3-methylimidazolium*BF4; 1,3-bis(diphenylphosphino)propane; Et3N / Ni(OAc)2 / 30 h / 130 °C 2: aq. HCl / 0.5 h View Scheme
参考文献
Journal of Chemical Research, , # 6 p. 388 - 389
反应条件
1.1: sodium hydride / toluene / 3 h / 70 - 80 °C 1.2: toluene / 3 h / 33 - 35 °C 1.3: toluene / 3 h / 5 - 20 °C 2.1: 92 percent / potassium carbonate / dimethylformamide / 3 h / 95 - 110 °C View Scheme
参考文献
Patel; Chauhan
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 1 p. 126 - 134
反应条件
potassium hydroxide in ethanol; water
参考文献
Karthikeyan, Mari S.; Holla, Bantwal S.; Shenoy, Shalini
Monatshefte fur Chemie, 2008 , vol. 139, # 6 p. 707 - 716
反应条件
1: 80 percent / NaH / 1.5 h / 80 °C 2: Ac2O / 2 h / 130 °C 3: CH2Cl2 / 0.5 h / Ambient temperature 4: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 5: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C View Scheme
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Pihuleac, Eva; Nordeen, Carl W.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1558 - 1564
反应条件
sodium hypochlorite in 1,4-dioxane
参考文献
Hong, Jian; Zhang, Zonghua; Lei, Huoxing; Cheng, Haiying; Hu, Yufang; Yang, Wanliang; Liang, Yinglin; Das, Debasis; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2525 - 2528
反应条件
1.1: sodium hydride / toluene / 3 h / 70 - 80 °C 1.2: toluene / 3 h / 33 - 35 °C 1.3: toluene / 3 h / 5 - 20 °C 2.1: 92 percent / potassium carbonate / dimethylformamide / 3 h / 95 - 110 °C 3.1: 92 percent / sodium hydroxide / H2O / 3 h / 80 - 90 °C View Scheme
参考文献
Vymed Corporation; SHETTY, B. Vithal
Patent: US2014/73631 A1, 2014 ;
反应条件
1: 80 percent / NaH / 1.5 h / 80 °C 2: Ac2O / 2 h / 130 °C 3: CH2Cl2 / 0.5 h / Ambient temperature 4: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 5: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C 6: 21.3 g / various solvent(s) / 24 h / 110 °C View Scheme
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Pihuleac, Eva; Nordeen, Carl W.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1558 - 1564
