3-苯基-3-(哌啶-1-基)丙酸甲酯合成路线 （共 7 条）
反应条件
lithium perchlorate
T=20°C; Michael addition; 2 h;
参考文献
Azizi, Najmedin; Saidi, Mohammad R.
Tetrahedron, 2004 , vol. 60, # 2 p. 383 - 387
反应条件
methyl ester of diphenylborinic acid in dimethyl sulfoxide
T=60°C; Mannich reaction; 12 h;
参考文献
Tanaka, Yusuke; Hasui, Tomoaki; Suginome, Michinori
Synlett, 2008 , # 8 p. 1239 - 1242
反应条件
1: methanol; pyridine; benzene
2: tetramethylammonium hydroxid, aqueous; toluene
View Scheme
参考文献
Pollard; Mattson
Journal of the American Chemical Society, 1956 , vol. 78, p. 4089
反应条件
triethylamine in methanol
T=60°C; 36 h;
参考文献
Renault; Guillon; Huard; Miel; Stiebing; Le Bourn; Boulouard; Dallemagne; Rault
Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 3 p. 217 - 223
反应条件
1: 94 percent / SOCl2 / 0.5 h / 20 °C
2: triethylamine / methanol / 36 h / 60 °C
View Scheme
参考文献
Renault; Guillon; Huard; Miel; Stiebing; Le Bourn; Boulouard; Dallemagne; Rault
Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 3 p. 217 - 223
反应条件
1: malonic acid / ethanol
2: 94 percent / SOCl2 / 0.5 h / 20 °C
3: triethylamine / methanol / 36 h / 60 °C
View Scheme
参考文献
Renault; Guillon; Huard; Miel; Stiebing; Le Bourn; Boulouard; Dallemagne; Rault
Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 3 p. 217 - 223
参考文献
Pollard; Mattson
Journal of the American Chemical Society, 1956 , vol. 78, p. 4089
