lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;

<b>Multi-step reaction with 2 steps<br /> </b>1: 2.) NEt₃*HF / 1.) CH₂Cl₂, -15 deg C, 15 min, 20 deg C, 30 min; 2.) 20 deg C, 4 h<br />2: 80 percent / K₂CO₃ / methanol / 20 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: sodium ethoxide / ethanol / 16 h / Heating<br />2: conc. hydrochloric acid / H₂O / 24 h / Heating<br />3: 61.5 percent / 2 N NaOH / 2 h / Ambient temperature<br />4: 92 percent / NaOH, CoCl₂ / H₂O / 48 h / 37 &deg;C / aminoacylase from Aspergillus<br />5: 2 N H₂SO₄, aq. NaNO₂ / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 92 percent / NaOH, CoCl₂ / H₂O / 48 h / 37 &deg;C / aminoacylase from Aspergillus<br />2: 2 N H₂SO₄, aq. NaNO₂ / Ambient temperature<br /> <br /> &nbsp;