4-溴甲基-3-甲氧基苯甲酸甲酯合成路线 （共 14 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 4 h; Heating;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 391-392 ;
反应条件
N-bromosuccinmide; azobisisobutyronitrile in tetrachloromethane
参考文献
Eli Lilly and Company
Patent: US6271227 B1, 2001 ;
US 6271227 B1
反应条件
bromine in tetrachloromethane
反应条件
1: 98 percent / acetyl chloride / 36 h 2: 64 percent / bromine / CCl4 / 4 h / Irradiation View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1771 - 1781
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; 2,2'-azo-bisisobutyronitrile in cyclohexane RefluxLarge scale reaction;
参考文献
Organic Process Research and Development, , vol. 13, # 1 p. 67 - 72
反应条件
1: 26 percent / K2CO3 / butan-2-one / 24 h / Heating 2: 90 percent / SnCl2*2H2O / ethanol / 18 h / 80 °C 3: 93 percent / 2,6-lutidine / CH2Cl2 / 24 h 4: 78 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h 5: 7.4 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h View Scheme
参考文献
Matassa; Brown; Bernstein; Shapiro; Maduskuie Jr.; Cronk; Vacek; Yee; Snyder; Krell; Lerman; Maloney
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2621 - 2629
反应条件
1: With copper(I) oxide in 1,4-dioxane T=95 - 100°C; Friedel Crafts alkylation; Large scale reaction; 2: With hydrogen in water; ethyl acetate T=25 - 30°C; P=3677.86 - 4413.43 Torr; Large scale reaction;
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Sampath, Aalla; Srinivas, Kurella; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 67 - 72
反应条件
1: 45 percent / silver(I) oxide / dioxane / 20 h / 60 °C 2: 1.) NaH / 1.) THF, 10 min, 2.) 30 min 3: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 2587.7 Torr View Scheme
参考文献
Matassa; Maduskuie Jr.; Shapiro; Hesp; Snyder; Aharony; Krell; Keith
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1781 - 1790
反应条件
in tetrahydrofuran; water; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US6284756 B1, 2001 ;
US 6284756 B1
参考文献
Eli Lilly and Company
Patent: US6025382 A1, 2000 ;
