4-羟基-2(1H)-喹啉酮合成路线 （共 93 条）
反应条件
1: With water; potassium hydroxide
Reflux;
2: in water
Acidic conditions;
参考文献
Hajdok, Szilvia; Conrad, Juergen; Leutbecher, Heiko; Strobel, Sabine; Schleid, Thomas; Beifuss, Uwe
Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7230 - 7237
反应条件
sodium hydride in toluene
T=100°C; 2 h;
参考文献
Jung; Park
Synthetic Communications, 2001 , vol. 31, # 8 p. 1195 - 1200
反应条件
ammonium hydroxide in ethanol
T=70°C; 4 h;
参考文献
Rudolf, Ondrej; Mrkvicka, Vladimir; Lycka, Antonin; Rouchal, Michal; Klasek, Antonin
Helvetica Chimica Acta, 2012 , vol. 95, # 8 p. 1352 - 1372
反应条件
sodium hydrogen telluride; acetic acid in ethanol
2 h; Heating;
参考文献
Shobana, N.; Shanmugam, P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 658
反应条件
1: 57 percent / conc. H2SO4 / 72 h / Ambient temperature
2: 87 percent / HCl(gas) / ethanol / 20 °C
3: 50 percent / H2 / PtO2 / methanol / Heating
View Scheme
参考文献
Sicker, D.; Rabe, A.; Zakrzewski, A.; Mann, G.
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 6 p. 1063 - 1070
反应条件
1: 63 percent
2: 57 percent / conc. H2SO4 / 72 h / Ambient temperature
3: 87 percent / HCl(gas) / ethanol / 20 °C
4: 50 percent / H2 / PtO2 / methanol / Heating
View Scheme
参考文献
Sicker, D.; Rabe, A.; Zakrzewski, A.; Mann, G.
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 6 p. 1063 - 1070
反应条件
1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 20 °C / |Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / |Inert atmosphere
3: silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 24 h / 60 °C / 750.08 Torr / |Schlenk technique
View Scheme
参考文献
Ishida, Tomonobu; Kikuchi, Satoshi; Yamada, Tohru
Organic Letters, 2013 , vol. 15, # 14 p. 3710 - 3713
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / |Inert atmosphere
2: silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 24 h / 60 °C / 750.08 Torr / |Schlenk technique
View Scheme
参考文献
Ishida, Tomonobu; Kikuchi, Satoshi; Yamada, Tohru
Organic Letters, 2013 , vol. 15, # 14 p. 3710 - 3713
反应条件
in methanol
T=20°C; 24 h;
参考文献
Pongratz, Erik; Kappe, Thomas
Monatshefte fuer Chemie, 1984 , vol. 115, p. 231 - 242
反应条件
1: diethyl ether
2: aq.-ethanolic NaOH
View Scheme
参考文献
Bornstein et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 2760
